Quantifying the clinical impact of tissue reflex testing for liquid biopsy ESR1 mutation–negative cases with low ctDNA tumor fraction (TF) in HR(+)HER2(-) breast cancer.
Du J, Quintanilha J, Huang R, Heilmann A, Kahn A, Rozenblit M, Chiang A, Pusztai L, Krop I, Winer E, Graf R, Mills J, Gasco Hernandez A, Levy M, Lustberg M. Quantifying the clinical impact of tissue reflex testing for liquid biopsy ESR1 mutation–negative cases with low ctDNA tumor fraction (TF) in HR(+)HER2(-) breast cancer. Journal Of Clinical Oncology 2025, 43: 1065-1065. DOI: 10.1200/jco.2025.43.16_suppl.1065.Peer-Reviewed Original ResearchMetastatic breast cancerComprehensive genomic profilingPositive percent agreementClinicogenomic databaseTumor fractionCtDNA sheddingBC patientsReflex testBreast cancerFirst-line standard of careResistance to estrogen deprivationTissue comprehensive genomic profilingMetastatic breast cancer patientsFalse negative rateFoundationOne Liquid CDxFirst-line standardMutation-negative casesCohort of patientsStandard of careESR1 mutationsTumor genotypeEstrogen deprivationFirst-lineAromatase inhibitorsClinical impactComparative analysis of PIK3CA mutation detection methods in the first-in-human phase 1/1b study of inavolisib.
Hilz S, Accordino M, Bedard P, Cervantes A, Gambardella V, Hamilton E, Italiano A, Jhaveri K, Juric D, Kalinsky K, Krop I, Oliveira M, Saura Manich C, Schmid P, Aimi J, Royer-Joo S, Schutzman J, Hutchinson K. Comparative analysis of PIK3CA mutation detection methods in the first-in-human phase 1/1b study of inavolisib. Journal Of Clinical Oncology 2025, 43: e13058-e13058. DOI: 10.1200/jco.2025.43.16_suppl.e13058.Peer-Reviewed Original ResearchMetastatic breast cancerHER2- metastatic breast cancerCtDNA testingNGS assaysTumor tissuesDetection concordanceTesting of tumor tissueFoundationOne Liquid CDxPIK3CA mutation testingFresh tumor tissueTissue-based testingBlood-based testOncogenic amino acid substitutionsBlood-based assayCatalytic subunit of PI3KSubunit of PI3KFoundation MedicineMutation detection methodsPIK3CA-mutationsTherapy regimenCtDNA sheddingAlpha catalytic subunitNG-TestReflex testAmino acid substitutions
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