2021
Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells
Dash BC, Duan K, Kyriakides TR, Hsia HC. Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells. Biomaterials Science 2021, 9: 5319-5329. PMID: 34190227, DOI: 10.1039/d1bm00162k.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorVascular smooth muscle cellsSmooth muscle cellsIntegrin β3Paracrine secretionMuscle cellsGrowth factorSecretion of bFGFMatrix metalloproteinase-2Proangiogenic growth factorsCell viabilityFibroblast growth factorHuman-induced pluripotent stemMetalloproteinase-2Ligand-integrin interactionExtracellular matrix microenvironmentSecretionPossible rolePositive feedback loopPaucity of researchMatrix microenvironmentIntegrin interactionPluripotent stemFibrillar collagenΒ3Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons
Li A, Cartwright S, Yu A, Ho SM, Schrode N, Deans PJM, Matos MR, Garcia MF, Townsley KG, Zhang B, Brennand KJ. Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons. STAR Protocols 2021, 2: 100580. PMID: 34151300, PMCID: PMC8188621, DOI: 10.1016/j.xpro.2021.100580.Peer-Reviewed Original ResearchConceptsCRISPR inhibitionGene expressionDCas9-KRAB systemEndogenous gene expressionMultiple target genesGene repressionGene activationTarget genesGene manipulationFusion proteinComplete detailsPluripotent stemExpressionGlutamatergic neuronsRepressionGenesPhenotypicProteinStemNeuronsActivationBrain diseasesInhibition
2020
Human Amniotic Membrane as a Novel Scaffold for Induced Pluripotent Stem Cell-Derived Kidney Organoids
Figetakis M, James K, Torres R, Chang W. Human Amniotic Membrane as a Novel Scaffold for Induced Pluripotent Stem Cell-Derived Kidney Organoids. Journal Of The American Society Of Nephrology 2020, 31: 145-145. DOI: 10.1681/asn.20203110s1145a.Peer-Reviewed Original Research
2012
Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced Neurons
Tran N, Ladran I, Brennand K. Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced Neurons. Schizophrenia Bulletin 2012, 39: 4-10. PMID: 23172000, PMCID: PMC3523925, DOI: 10.1093/schbul/sbs127.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
Klf4 Interacts Directly with Oct4 and Sox2 to Promote Reprogramming
Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W. Klf4 Interacts Directly with Oct4 and Sox2 to Promote Reprogramming. Stem Cells 2009, 27: 2969-2978. PMID: 19816951, DOI: 10.1002/stem.231.Peer-Reviewed Original ResearchConceptsInduced pluripotent stemEndogenous KLF4Sets of transcription factorsInduced pluripotent stem cellsTandem zinc fingerEmbryonic stemDominant negative mutantInduced iPS cellsMouse ES cellsSomatic cell reprogrammingWild-type Klf4Zinc fingerPluripotent stemTranscription factorsC-terminusIPS cellsInhibit reprogrammingEctopic expressionTarget genesNanog promoterSomatic cellsSOX2Cell reprogrammingES cellsKLF4
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply