Biomimetic membrane in a microfluidic chip for the electrical and optical monitoring of biological reactions
Mion D, Bunel L, Ramakrishnan S, Heo P, Pincet F. Biomimetic membrane in a microfluidic chip for the electrical and optical monitoring of biological reactions. Nature Protocols 2025, 1-32. PMID: 40461799, DOI: 10.1038/s41596-025-01171-7.Peer-Reviewed Original ResearchMicrofluidic chipTwo-dimensional bilayersBiomimetic membranesChip fabricationSingle-particleMicrofluidic channelOptical microscopyElectrical readoutResin moldMicrofluidic setupMembrane typeOptical monitoringChipPoly(dimethylsiloxaneBiological membranesPhysicochemical cuesFluid lipidsBilayerCharacteristics of biological membranesChannelComprehensive procedureBilayer leafletsMolecular reactionsGeneration of Orthogonal Gradients of the Matrix Stiffness and Chemotactic Cues in a Suspended Array of Hydrogel to Study hMSCs Migration
Xu Z, Ponek A, Thomas J, Qyang Y. Generation of Orthogonal Gradients of the Matrix Stiffness and Chemotactic Cues in a Suspended Array of Hydrogel to Study hMSCs Migration. ACS Sensors 2025, 10: 1722-1728. PMID: 40021359, DOI: 10.1021/acssensors.4c02793.Peer-Reviewed Original ResearchConceptsMatrix stiffnessChemotactic cuesHuman mesenchymal stem cellsHydrogel cylindersCell migrationDevice working principleMigration of human mesenchymal stem cellsFactor 1 alphaCellular contextOrthogonal gradientsReplica moldingGlass substratesCell migration studiesDevice fabricationWorking principleMicrofluidic devicesIn vitro assaysHydrogelsStiffnessCell typesSuspended arrayMesenchymal stem cellsConcentration gradientPoly(dimethylsiloxaneCylinder
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