2001
Ion pump sorting in polarized renal epithelial cells
Caplan M. Ion pump sorting in polarized renal epithelial cells. Kidney International 2001, 60: 427-430. PMID: 11473621, DOI: 10.1046/j.1523-1755.2001.060002427.x.Peer-Reviewed Original ResearchConceptsIon transport proteinsRenal epithelial cellsSubcellular localizationTransport proteinsPolarized renal epithelial cellsEpithelial cellsProtein subcellular localizationBasolateral domainMultiple complex signalsPlasma membranePolarized distributionIon pumpsProteinCellsMembraneLocalizationDomain
1999
A diffusion barrier maintains distribution of membrane proteins in polarized neurons
Winckler B, Forscher P, Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 1999, 397: 698-701. PMID: 10067893, DOI: 10.1038/17806.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAxonsBiological TransportCell CompartmentationCell MembraneCell PolarityCells, CulturedCytoskeletonDiffusionDimethyl SulfoxideLeukocyte L1 Antigen ComplexMembrane GlycoproteinsMembrane ProteinsMicrospheresNeural Cell Adhesion MoleculesNeuronsRatsReceptors, AMPAThy-1 AntigensConceptsMembrane proteinsDiffusion barrierObvious physical barriersPlasma membrane domainsLateral mobilityOptical tweezersCell-cell contactMembrane domainsPresumptive domainPolarized neuronsPlasma membraneCytoskeletal componentsPolarized distributionF-actinDiffusion of proteinsDistinct domainsBasolateral surfaceMembrane markersProteinSpecialized domainsInitial segmentTight junctionsAsymmetric distributionPhysical barrierTweezers
1989
Polarized distribution of Na+,K+-ATPase in giant cells elicited in vivo and in vitro.
Vignery A, Niven-Fairchild T, Ingbar DH, Caplan M. Polarized distribution of Na+,K+-ATPase in giant cells elicited in vivo and in vitro. Journal Of Histochemistry & Cytochemistry 1989, 37: 1265-1271. PMID: 2546991, DOI: 10.1177/37.8.2546991.Peer-Reviewed Original ResearchConceptsPlasma membranePolarized distributionAdherent plasma membraneGiant cell differentiationLysosomal membrane antigenAlpha subunit synthesisSuitable model systemSpecialized functionsCell differentiationBiochemical studiesCell surfaceLysosomal componentsCell formationATPase expressionGiant cell formationModel systemATPaseExpressionCellsAnkyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells.
Morrow J, Cianci C, Ardito T, Mann A, Kashgarian M. Ankyrin links fodrin to the alpha subunit of Na,K-ATPase in Madin-Darby canine kidney cells and in intact renal tubule cells. Journal Of Cell Biology 1989, 108: 455-465. PMID: 2537316, PMCID: PMC2115445, DOI: 10.1083/jcb.108.2.455.Peer-Reviewed Original ResearchConceptsMadin-Darby canine kidney cellsCanine kidney cellsK-ATPaseAlpha subunitMolecular mechanismsMDCK cellsMinor membrane proteinsDistribution of fodrinErythrocyte ankyrinConfluent MDCK cellsBinding of ankyrinKidney cellsHuman erythrocyte ankyrinRenal epithelial cellsCytoplasmic domainNonerythroid cellsMembrane proteinsCortical cytoskeletonBasolateral domainMembrane skeletonPolarized distributionAnkyrinBasolateral marginsCell developmentErythrocyte band 3
1986
Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.
Ingber DE, Madri JA, Jamieson JD. Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. American Journal Of Pathology 1986, 122: 129-39. PMID: 3942197, PMCID: PMC1888129.Peer-Reviewed Original ResearchConceptsDistinct membrane domainsEpithelial cell-cell interactionsCell shape changesCell-cell interactionsAcinar tumor cellsMembrane domainsTumor cellsBasement membranePolarized distributionSpatial organizersGolgi complexProtein synthesisIndividual cellsCell surfaceLipid dropletsIntracellular actinPancreatic acinar carcinomaJunctional complexesEpithelial tumor cellsCell contactCytoskeletal alterationsAmniotic basement membraneEpithelial orientationIntact basement membraneZymogen granules
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