2020
120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis
ABULIZI A, CARDONE R, SIEBEL S, KUNG C, KIBBEY R. 120-LB: Small Molecule Activator of Pyruvate Kinase Regulates In Vivo Glucose Homeostasis. Diabetes 2020, 69 DOI: 10.2337/db20-120-lb.Peer-Reviewed Original ResearchEndogenous glucose productionNonalcoholic fatty liver diseaseWhole-body insulin sensitivityHFD-fed ratsInsulin sensitivityAgios PharmaceuticalsRegular chowInsulin resistanceBody weightInsulin-stimulated peripheral glucose uptakeGlucose productionHigh-fat diet ratsHyperinsulinemic-euglycemic clamp studiesSmall molecule activatorsMuscle triglyceride contentSevere liver dysfunctionFatty liver diseasePeripheral insulin sensitivityAmerican Diabetes AssociationWhole-body energy expenditurePeripheral glucose uptakeHigh-fat dietType 2 diabetesFat diet ratsPotential therapeutic target
2012
The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats
Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, Samuel VT. The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats. Endocrinology 2012, 154: 36-44. PMID: 23161873, PMCID: PMC3529388, DOI: 10.1210/en.2012-1725.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisResponse element-binding proteinCarbohydrate response element-binding proteinASO treatmentHepatic expressionNovo lipogenesisElement-binding proteinInsulin-stimulated peripheral glucose uptakeNonalcoholic fatty liver diseaseAntisense oligonucleotideMale Sprague-Dawley ratsHepatic de novo lipogenesisFructose-fed groupHepatic insulin responsivenessFatty liver diseaseFructose fed ratsPeripheral glucose uptakeHyperinsulinemic-euglycemic clampHigh-fat dietHepatic lipid contentHepatic triglyceride secretionHepatic insulin sensitivitySprague-Dawley ratsPlasma triglyceride concentrationsPlasma uric acid
2002
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. Journal Of Clinical Investigation 2002, 109: 1321-1326. PMID: 12021247, PMCID: PMC150979, DOI: 10.1172/jci14955.Peer-Reviewed Original ResearchConceptsAspirin treatmentInsulin resistanceTolerance testPlasma glucoseInsulin-stimulated peripheral glucose uptakeHigh-dose aspirin treatmentMixed meal tolerance testType 2 diabetic subjectsMixed-meal tolerance testType 2 diabetes mellitusHigh-dose aspirinWeeks of treatmentC-reactive proteinPeripheral glucose uptakeHyperinsulinemic-euglycemic clampType 2 diabetesPlasma insulin concentrationHepatic glucose productionFatty acid levelsDiabetes mellitusDiabetic subjectsTotal cholesterolGlucose toleranceInsulin clearanceTissue inflammation
1991
The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats
Bowen L, Stein P, Stevenson R, Shulman G. The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 1991, 40: 1025-1030. PMID: 1943727, DOI: 10.1016/0026-0495(91)90124-f.Peer-Reviewed Original ResearchConceptsHepatic glucose productionInsulin-induced suppressionObese animalsObese Zucker ratsGlucose disposalInsulin sensitivityDrug treatmentFree fatty acidsZucker ratsHigher insulin infusion ratesEuglycemic hyperinsulinemic clamp techniqueInsulin-resistant animal modelsPeripheral glucose disposalHyperinsulinemic clamp techniquePeripheral glucose uptakeInsulin infusion rateInsulin clampInsulin suppressionKetone levelsInfusion rateAnimal modelsClamp techniqueEffect of CPLean animalsLipid metabolism
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply