2003
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)
Hernandez‐Avila C, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1). American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 118B: 60-65. PMID: 12627468, DOI: 10.1002/ajmg.b.10054.Peer-Reviewed Original ResearchConceptsCortisol responseAsn40 alleleAsn40Asp polymorphismAsp40 alleleCortisol concentrationsCortisol time curveMu-opioid receptor proteinOpioid antagonist naloxoneMin post infusionPeak cortisol responsePlasma ACTH concentrationsEnhanced cortisol responseHigher cortisol concentrationsWarrants further investigationAsp40 variantIntravenous naloxoneOpioid blockadeNaloxone infusionAntagonist naloxonePlasma ACTHACTH concentrationsAgonist effectsPost infusionHealthy subjectsClinical relevance
2001
Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder
Rasmusson A, Lipschitz D, Wang S, Hu S, Vojvoda D, Bremner J, Southwick S, Charney D. Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biological Psychiatry 2001, 50: 965-977. PMID: 11750893, DOI: 10.1016/s0006-3223(01)01264-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdrenal axis regulationAdrenocorticotropic hormonePremenopausal womenPosttraumatic stress disorder subjectsPosttraumatic stress disorder groupCortisol responseStress disorderAxis regulationCortisol levelsUrinary free cortisol excretionDisorder subjectsUrinary free cortisol measurementChronic posttraumatic stress disorderDisorder groupAdrenocorticotropin stimulation testPeak cortisol responseMenstrual cycle phaseBaseline cortisol levelsGreater cortisol responseBaseline adrenocorticotropic hormoneLH surgeExogenous corticotropinPsychotropic medicationsStimulation test
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