2003
Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure
Oliveto A, Sevarino K, McCance-Katz E, Benios T, Poling J, Feingold A. Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure. Behavioural Pharmacology 2003, 14: 97-109. PMID: 12658070, DOI: 10.1097/00008877-200303000-00001.Peer-Reviewed Original ResearchConceptsAlpha2-adrenergic antagonist yohimbineNovel-response drug discrimination procedureAlpha2-adrenergic agonist clonidineOpioid-dependent humansPlacebo-appropriate respondingOpioid antagonist naloxoneClonidine-induced changesDose-related increaseEffects of yohimbineDoses of naloxoneDrug discrimination procedureOpioid withdrawalAdrenergic mechanismsAntagonist yohimbineAgonist clonidineAntagonist naloxoneOpioid antagonistClonidineLow doseNaloxoneTraining doseYohimbineDrug conditionsDiscrimination procedureDoseAssociation between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)
Hernandez‐Avila C, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1). American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 118B: 60-65. PMID: 12627468, DOI: 10.1002/ajmg.b.10054.Peer-Reviewed Original ResearchConceptsCortisol responseAsn40 alleleAsn40Asp polymorphismAsp40 alleleCortisol concentrationsCortisol time curveMu-opioid receptor proteinOpioid antagonist naloxoneMin post infusionPeak cortisol responsePlasma ACTH concentrationsEnhanced cortisol responseHigher cortisol concentrationsWarrants further investigationAsp40 variantIntravenous naloxoneOpioid blockadeNaloxone infusionAntagonist naloxonePlasma ACTHACTH concentrationsAgonist effectsPost infusionHealthy subjectsClinical relevance
2002
Butorphanol and nalbuphine in opioid-dependent humans under a naloxone discrimination procedure
Oliveto A, Sevarino K, McCance-Katz E, Feingold A. Butorphanol and nalbuphine in opioid-dependent humans under a naloxone discrimination procedure. Pharmacology Biochemistry And Behavior 2002, 71: 85-96. PMID: 11812511, DOI: 10.1016/s0091-3057(01)00637-2.Peer-Reviewed Original ResearchConceptsNaloxone-appropriate respondingOpioid antagonist naloxoneDose-related increaseAntagonist naloxoneNovel-response drug discrimination procedureOpioid agonist/antagonistOpioid-dependent humansDoses of naloxoneDiscriminative stimulus effectsDrug discrimination procedureAgonists/antagonistsAppropriate respondingLow doseHigh doseNaloxoneSelf-reported effectsDiscrimination procedureDrug conditionsHigh dosesNalbuphineButorphanolDosesDoseRespondingPlacebo
2000
Patterns of response to acute naloxone infusion in Tourette's syndrome
van Wattum P, Chappell P, Zelterman D, Scahill L, Leckman J. Patterns of response to acute naloxone infusion in Tourette's syndrome. Movement Disorders 2000, 15: 1252-1254. PMID: 11104215, DOI: 10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsTourette syndromeTic behaviorsOpioid antagonist naloxoneDose-related effectsDose-response effectExpression of TSRandomized dosesAntagonist naloxoneNaloxone infusionOpioid receptorsLow doseHigh doseEarlier pilot studyPattern of responseSyndromeNaloxoneTS subjectsPilot studySignificant decreaseSignificant increaseDoseDifferent dosagesOpposite effectSubjectsVideotaped recordings
1990
Maintenance of morphine dependence by naloxone in acutely dependent mice.
Sofuoglu M, Sato J, Takemori A. Maintenance of morphine dependence by naloxone in acutely dependent mice. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 841-846. PMID: 2395116, DOI: 10.1016/s0022-3565(25)12745-6.Peer-Reviewed Original ResearchConceptsMorphine sulfateNaloxone hydrochloridePriming doseED50 valuesSingle doseControl groupMorphine-pretreated miceOpioid antagonist naloxoneSigns of withdrawalDevelopment of dependenceMS injectionDependent miceAntagonist naloxoneMorphine dependenceMiceDoseFormer groupMS 24NaloxoneHrPretreatmentWithdrawalInjectionGroupDays
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