2023
Some Offset Restoration Options Can Paradoxically Lead to Decreased Range of Motion in Primary Total Hip Arthroplasty: A 3-Dimensional Computer Simulation Study
Pour A, Donnelley C, Tung W, Tommasini S, Wiznia D. Some Offset Restoration Options Can Paradoxically Lead to Decreased Range of Motion in Primary Total Hip Arthroplasty: A 3-Dimensional Computer Simulation Study. The Journal Of Arthroplasty 2023, 39: 514-519.e3. PMID: 37625464, PMCID: PMC10843541, DOI: 10.1016/j.arth.2023.08.057.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyRange of motionPrimary total hip arthroplastyHip flexionHip arthroplastyParadoxical increaseHigh-offset stemsRobotic arm-assisted total hip arthroplastyGroup of patientsSubset of patientsSagittal pelvic tiltVarus neckMaximum internal rotationPelvic tiltOptimizing outcomesImplant design featuresDecreased rangeHip extensionExternal rotationImplant choiceProsthetic headMaximum external rotationFlexionImpingement riskLiner use
2020
Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease.
Ter Horst KW, Vatner DF, Zhang D, Cline GW, Ackermans MT, Nederveen AJ, Verheij J, Demirkiran A, van Wagensveld BA, Dallinga-Thie GM, Nieuwdorp M, Romijn JA, Shulman GI, Serlie MJ. Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Diabetes Care 2020, 44: 489-498. PMID: 33293347, PMCID: PMC7818337, DOI: 10.2337/dc20-1644.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseDe novo lipogenesisFatty liver diseaseBariatric surgeryLiver diseaseImpaired insulin-mediated suppressionGlucose productionHepatic de novo lipogenesisPeripheral glucose metabolismHyperinsulinemic-euglycemic clampType 2 diabetesInsulin-mediated suppressionInsulin-resistant subjectsHepatic insulin resistanceLiver biopsy samplesSuppress glucose productionLipogenic transcription factorsInsulin-mediated regulationObese subjectsInsulin resistanceAcute increaseNovo lipogenesisGlucose metabolismBiopsy samplesParadoxical increase
2017
Removing Cerebrospinal Fluid Antibody Orders from the Test Menu Results in a Dramatic Decrease in Order Volume
Beal S, Tremblay E, Harris N, Rand K. Removing Cerebrospinal Fluid Antibody Orders from the Test Menu Results in a Dramatic Decrease in Order Volume. The Journal Of Applied Laboratory Medicine 2017, 2: 47-54. PMID: 33636964, DOI: 10.1373/jalm.2017.023515.Peer-Reviewed Original ResearchCerebrospinal fluidTest menuTest order volumeB. burgdorferiComputerized physician order entry systemPhysician order entry systemTest ordersCMV PCROrder entry systemAntibody testingT. gondiiToxoplasma gondiiParadoxical increaseCompensatory increaseUseful testSubstantial cost savingsBorrelia burgdorferiBurgdorferiGondiiCPOELaboratory testsEntry systemDramatic decreaseProvidersCost savings
2015
Paradoxical changes in innate immunity in aging: recent progress and new directions
Montgomery RR, Shaw AC. Paradoxical changes in innate immunity in aging: recent progress and new directions. Journal Of Leukocyte Biology 2015, 98: 937-943. PMID: 26188078, PMCID: PMC4661037, DOI: 10.1189/jlb.5mr0315-104r.Peer-Reviewed Original ResearchConceptsImmune responseInnate immune changesInnate immune responseCytokine levelsInappropriate elevationImmune changesNaïve cell populationT cellsAdaptive immunityViral infectionParadoxical increaseInnate immunityMultiple cell typesParadoxical changesCell populationsActivation stateImmunityCell typesSevere consequencesResponseTissue contextImmunosenescenceVaccinationPopulationInfectionHypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role
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