2016
Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome
Kulke MH, Hörsch D, Caplin ME, Anthony LB, Bergsland E, Öberg K, Welin S, Warner RR, Lombard-Bohas C, Kunz PL, Grande E, Valle JW, Fleming D, Lapuerta P, Banks P, Jackson S, Zambrowicz B, Sands AT, Pavel M. Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome. Journal Of Clinical Oncology 2016, 35: 14-23. PMID: 27918724, DOI: 10.1200/jco.2016.69.2780.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Agents, HormonalDefecationDiarrheaDouble-Blind MethodFemalegamma-GlutamyltransferaseGastrointestinal AgentsHumansHydroxyindoleacetic AcidMaleMalignant Carcinoid SyndromeMiddle AgedNauseaOctreotidePeptides, CyclicPhenylalaninePyrimidinesSomatostatinTryptophan HydroxylaseConceptsDouble-blind treatment periodOpen-label extensionTelotristat ethylTryptophan hydroxylase inhibitorBM frequencyCarcinoid syndromeWeek 12Treatment periodHydroxylase inhibitorPlacebo-controlled phase III studyPrimary end pointSomatostatin analogue therapyBowel movement frequencyNew safety signalsPhase III studyGamma-glutamyl transferaseAsymptomatic increaseMild nauseaAnalogue therapyIII studyMethods PatientsSomatostatin analoguesSafety signalsPlaceboPatients
2002
Secondary hormonal therapies in the treatment of prostate cancer
OH W. Secondary hormonal therapies in the treatment of prostate cancer. Urology 2002, 60: 87-92. PMID: 12231058, DOI: 10.1016/s0090-4295(02)01581-9.Peer-Reviewed Original ResearchConceptsSecond-line hormonal therapyAndrogen-independent prostate cancerSecondary hormonal therapyProstate-specific antigenHormone therapyProstate cancerSerum prostate-specific antigenEvidence of tumor growthTreatment of prostate cancerPSA level decreaseAdrenal steroid synthesisTreatment of patientsProgression of diseaseAdrenal insufficiencyEstrogen therapyOral therapyAsymptomatic increaseAsymptomatic patientsSurvival benefitSymptomatic improvementSymptomatic progressionPoor prognosisTreatment optionsTumor growthLiver toxicity
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