2011
The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch–Schönlein purpura
Shin J, Song K, Kim H, Cho N, Kim J, Kim H, Lee J. The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch–Schönlein purpura. British Journal Of Dermatology 2011, 164: 1348-1355. PMID: 21410660, DOI: 10.1111/j.1365-2133.2011.10295.x.Peer-Reviewed Original ResearchConceptsPathogenesis of Henoch-Schonlein purpuraHenoch-Schonlein purpuraPeripheral blood samplesMatrix metalloproteinasesMMP-26MMP-8Gene expression profilesDuration of steroid administrationMMP-9Convalescent stageHenoch-Schonlein purpura patientsAcute stageMMP-10Expression of MMP-26MMP-19Expression profile of matrix metalloproteinasesAssociated with decreased expressionBlood samplesMMP-1TIMP-1 levelsLevels of matrix metalloproteinasesProfiles of matrix metalloproteinasesSoft tissue edemaInducer of matrix metalloproteinasesMMP-8 expression
2010
Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis
Pomerantz M, Shrestha Y, Flavin R, Regan M, Penney K, Mucci L, Stampfer M, Hunter D, Chanock S, Schafer E, Chan J, Tabernero J, Baselga J, Richardson A, Loda M, Oh W, Kantoff P, Hahn W, Freedman M. Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis. PLOS Genetics 2010, 6: e1001204. PMID: 21085629, PMCID: PMC2978684, DOI: 10.1371/journal.pgen.1001204.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProstate cancer riskChromosome 10q11Risk allelesProstate tissueProtein-coding regionsInfluence multiple genesDisease risk allelesGrowth of breast epithelial cellsAssociated with prostate cancer riskGrowth of prostate epithelial cellsCancer riskEpithelial cellsHistologically normal prostate tissueHuman prostate tumorigenesisMalignant prostate tissueAssociated with decreased expressionBreast epithelial cellsProstate epithelial cellsAssociated with increased expressionNormal prostate tissueAssociation studiesGermline variationMultiple genesMSMB expression
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