2024
Fine Particulate Matter, Noise Pollution, and Greenspace and Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Cohort.
Thomas A, Rhee J, Fisher J, Horner M, Jones R. Fine Particulate Matter, Noise Pollution, and Greenspace and Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Cohort. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 857-860. PMID: 38497801, PMCID: PMC11147690, DOI: 10.1158/1055-9965.epi-23-1413.Peer-Reviewed Original ResearchProstate cancer riskAssociated with prostate cancer riskCancer riskNoise exposureMale participantsArea Deprivation IndexFamily history of prostate cancerFine particulate matterTrial cohortEnrollment addressHistory of prostate cancerDeprivation indexPotential risk factorsGreenspace exposureEstimate associationsMultipollutant modelsCox regression modelsFamily historyProstate cancerSingle-pollutantCases of prostate cancerProspective ProstateRisk factorsU.S. studiesIncident prostate cancer risk
2010
Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis
Pomerantz M, Shrestha Y, Flavin R, Regan M, Penney K, Mucci L, Stampfer M, Hunter D, Chanock S, Schafer E, Chan J, Tabernero J, Baselga J, Richardson A, Loda M, Oh W, Kantoff P, Hahn W, Freedman M. Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis. PLOS Genetics 2010, 6: e1001204. PMID: 21085629, PMCID: PMC2978684, DOI: 10.1371/journal.pgen.1001204.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProstate cancer riskChromosome 10q11Risk allelesProstate tissueProtein-coding regionsInfluence multiple genesDisease risk allelesGrowth of breast epithelial cellsAssociated with prostate cancer riskGrowth of prostate epithelial cellsCancer riskEpithelial cellsHistologically normal prostate tissueHuman prostate tumorigenesisMalignant prostate tissueAssociated with decreased expressionBreast epithelial cellsProstate epithelial cellsAssociated with increased expressionNormal prostate tissueAssociation studiesGermline variationMultiple genesMSMB expression
2009
Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression
Pomerantz M, Beckwith C, Regan M, Wyman S, Petrovics G, Chen Y, Hawksworth D, Schumacher F, Mucci L, Penney K, Stampfer M, Chan J, Ardlie K, Fritz B, Parkin R, Lin D, Dyke M, Herman P, Lee S, Oh W, Kantoff P, Tewari M, McLeod D, Srivastava S, Freedman M. Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression. Cancer Research 2009, 69: 5568-5574. PMID: 19549893, PMCID: PMC2884104, DOI: 10.1158/0008-5472.can-09-0387.Peer-Reviewed Original ResearchConceptsProstate cancer risk lociCancer risk lociRisk lociTumor tissuesAssociated with prostate cancer riskRisk variantsInherited risk variantsRadical prostatectomy tissueProstate cancer riskRNA expressionRisk allele statusRisk single nucleotide polymorphismsMYC expression levelsProstatectomy tissueProstatectomy specimensTranscript levels of multiple genesCis-acting enhancerProstate tissueNext generation sequencingSingle nucleotide polymorphismsGermline DNAMYC expressionCancer riskPaired germline DNAProto-oncogene
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