Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1
Siew E, Chan K, Williams G, Ross D, Inayat-Hussain S. Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1. Free Radical Biology And Medicine 2012, 53: 1616-1624. PMID: 22687461, DOI: 10.1016/j.freeradbiomed.2012.05.046.Peer-Reviewed Original ResearchConceptsForward genetic approachDNA damageWild-type cellsDNA-damaging agentsPotential tumor suppressor geneSpecific mechanism-based inhibitorsTumor suppressor geneAntisense sequencesMouse thymoma cellsFAU geneGenetic approachesReactive oxygen speciesSuppressor geneDetoxification enzymesPlasmid constructsMechanism-based inhibitorsEmpty vectorApoptotic effectsQuinone oxidoreductase 1ApoptosisOxygen speciesThymoma cellsNQO1 upregulationGenesDownregulation
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