2012
Follicular helper T cells in immunity and systemic autoimmunity
Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nature Reviews Rheumatology 2012, 8: 337-347. PMID: 22549246, PMCID: PMC3604997, DOI: 10.1038/nrrheum.2012.58.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsSelf-reactive B cell clonesT helper cell populationSystemic lupus erythematosusSystemic autoimmune diseaseNormal immune responseT cell helpB cell clonesB cell survivalLupus erythematosusAutoantibody productionAutoimmune diseasesSystemic autoimmunityImmune responseAutoimmunityKey regulatorErythematosusCellsDiseaseImmunityT cells that promote B‐Cell maturation in systemic autoimmunity
Weinstein JS, Hernandez SG, Craft J. T cells that promote B‐Cell maturation in systemic autoimmunity. Immunological Reviews 2012, 247: 160-171. PMID: 22500839, PMCID: PMC3334351, DOI: 10.1111/j.1600-065x.2012.01122.x.Peer-Reviewed Original ResearchConceptsSystemic autoimmunityT cellsB cell maturationExtrafollicular fociGerminal centersB cellsTfh cellsImmune responseFollicular helper T cellsT cell-dependent immune responsesEnd-organ injuryB cell folliclesSystemic autoimmune diseaseTfh cell developmentHuman Tfh cellsSelf-reactive B cellsT helper cellsHelper T cellsSecondary lymphoid organsNormal immune responseT cell helpPlasma cell formationPathogenic autoantibodiesLymph nodesAutoimmune diseases
2011
An Innate Role for IL-17
Dominguez-Villar M, Hafler DA. An Innate Role for IL-17. Science 2011, 332: 47-48. PMID: 21454778, DOI: 10.1126/science.1205311.Peer-Reviewed Original ResearchConceptsImmune responseImmune dysregulation polyendocrinopathyAbnormal immune responseRegulatory immune cellsRegulatory T cellsHuman autoimmune disordersCytokine interleukin-17Normal immune responseTranscription factor Foxp3IL-17Interleukin-17Autoimmune disordersAutoimmune diseasesImmune cellsImmune system processFOXP3 geneFactor Foxp3T cellsImmune systemFungal infectionsGenetic mutationsHuman genetic mutationsCytokinesInfectionCell types
2008
CD4 T Cells That Promote Extrafollicular B Cell Responses
Poholek A, Odegard J, Craft J. CD4 T Cells That Promote Extrafollicular B Cell Responses. The FASEB Journal 2008, 22: 846.3-846.3. DOI: 10.1096/fasebj.22.1_supplement.846.3.Peer-Reviewed Original ResearchCD4 T cellsExtrafollicular B cell responsesB cell responsesIL-21T cellsLO cellsP-selectin glycoprotein ligand-1Extrafollicular sitesTCR transgenic CD4 T cellsCell responsesSelectin glycoprotein ligand-1Follicular helper T cellsTransgenic CD4 T cellsT FH cellsB cell folliclesHelper T cellsNormal immune responseExtrafollicular cellsAdoptive transferMurine lupusFH cellsIL-4Extrafollicular responseImmune responseNovel subset
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