2021
Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons
Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, Grandes P, Lovinger DM, Stella N. Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons. European Journal Of Neuroscience 2021, 54: 4934-4952. PMID: 34216157, PMCID: PMC9377695, DOI: 10.1111/ejn.15381.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsR KO miceAmphetamine sensitizationKO miceMotor coordinationSpiny neuronsImpaired motor coordinationInvolvement of CBCannabinoid 1 receptorCannabinoid CB1 receptorsCB1 receptorsNeuronal subpopulationsCannabimimetic responsesInhibitory neuronsSpontaneous locomotionR activationR expressionMiceMouse linesKnockout backgroundNeuronsSpecific CBNew functional roleSensitizationDifferent behavioral responses
2019
Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
Kim S, Shan P, Hwangbo C, Zhang Y, Min J, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell 2019, 18: e12914. PMID: 30790400, PMCID: PMC6516428, DOI: 10.1111/acel.12914.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Senescence-related gene expressionLung integritySenescence-associated genesReceptor 4New functional roleLung ECsInnate immune receptor toll-like receptor 4Immune receptor toll-like receptor 4Role of TLR4Endothelial Toll-like receptor 4Receptor Toll-like receptor 4Epigenetic regulationHistone H4Epigenetic suppressionTLR4-/- miceGene expressionEndogenous p16Molecular mechanismsWild-type miceNovel roleExpression of p16Lung endothelial cellsFunctional roleDistinct roles
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