2022
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma
Thadathil N, Selvarani R, Mohammed S, Nicklas E, Tran A, Kamal M, Luo W, Brown J, Lawrence M, Borowik A, Miller B, Van Remmen H, Richardson A, Deepa S. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma. Aging Cell 2022, 21: e13676. PMID: 35869934, PMCID: PMC9381894, DOI: 10.1111/acel.13676.Peer-Reviewed Original ResearchConceptsSod1KO miceHepatocellular carcinomaQ treatmentCellular senescenceSenescence-associated secretory phenotype factorsMarkers of necroptosisSod1 knockout miceChronic liver diseaseMarkers of inflammationMonths of ageExpression of p16WT levelsSenolytic treatmentLiver diseaseReduced inflammationCu/Zn-superoxide dismutaseMacrophage levelsLiver fibrosisPhenotype factorsLiver cancerNecrostatin-1sKnockout miceAge-associated pathologiesMice nullInflammation
2019
Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
Kim S, Shan P, Hwangbo C, Zhang Y, Min J, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell 2019, 18: e12914. PMID: 30790400, PMCID: PMC6516428, DOI: 10.1111/acel.12914.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Senescence-related gene expressionLung integritySenescence-associated genesReceptor 4New functional roleLung ECsInnate immune receptor toll-like receptor 4Immune receptor toll-like receptor 4Role of TLR4Endothelial Toll-like receptor 4Receptor Toll-like receptor 4Epigenetic regulationHistone H4Epigenetic suppressionTLR4-/- miceGene expressionEndogenous p16Molecular mechanismsWild-type miceNovel roleExpression of p16Lung endothelial cellsFunctional roleDistinct roles
2007
Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature
Yıldız I, Usubütün A, Fırat P, Ayhan A, Küçükali T. Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature. Pathology - Research And Practice 2007, 203: 445-449. PMID: 17543474, DOI: 10.1016/j.prp.2007.03.010.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCervix UteriCyclin-Dependent Kinase Inhibitor p16FemaleHumansImmunohistochemistryNeoplasms, Squamous CellPapillomaviridaePapillomavirus InfectionsPredictive Value of TestsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexUterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsLSIL casesHSIL casesCervical epithelial dysplasiaFull-thickness stainingHR-HPV positivityImmunohistochemical p16 expressionCervical cancer precursorsHPV-positive casesHR-HPV typesFull thicknessExpression of p16LSIL groupRare stainingHR-HPVHPV infectionP16 positivityHPV typesHPV typingLesion gradingCancer precursorsCervix epitheliumEpithelial dysplasiaImmunohistochemical panelInfection positivityPositivity rate
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