Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease
Liu N, Xu J, Liu H, Zhang S, Li M, Zhou Y, Qin W, Li M, Yu C. Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease. PLOS Genetics 2021, 17: e1009363. PMID: 33630843, PMCID: PMC7906391, DOI: 10.1371/journal.pgen.1009363.Peer-Reviewed Original ResearchConceptsTranscriptome-wide association studyGenome-wide association studiesAssociation studiesAD-GWASHippocampal gene expressionGene expressionAlzheimer's diseaseMeta-analyses of GWASIdentified multiple susceptibility lociGenes associated with ADGenome-wide association dataMultiple susceptibility lociAD-related genesAmyloid beta formationHippocampal expressionSusceptibility lociAmyloid-betaNeurobiological pathwaysTranscriptome dataHippocampal volumePathway analysisGenesAssociation dataMeta-analysisCognitively normal elderly individuals
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