2016
Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension
Drozd K, Ahmadi A, Deng Y, Jiang B, Petryk J, Thorn S, Stewart D, Beanlands R, deKemp RA, DaSilva JN, Mielniczuk LM. Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension. Journal Of Nuclear Cardiology 2016, 24: 1979-1989. PMID: 27688036, DOI: 10.1007/s12350-016-0663-4.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionRV FDG uptakePositron emission tomographyFDG uptakeFTHA uptakeFatty acid metabolismArterial hypertensionRV functionMacitentan treatmentRat modelSevere pulmonary arterial hypertensionWeek 5Effect of macitentanImproved RV functionRV systolic pressureWeeks of hypoxiaEndothelin receptor antagonistsRV ejection fractionHypoxia rat modelSingle subcutaneous injectionMale Sprague-DawleyAcid metabolismMyocardial energy metabolismPAH severitySugen 5416
2015
AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
Sung MM, Zordoky BN, Bujak AL, Lally JS, Fung D, Young ME, Horman S, Miller EJ, Light PE, Kemp BE, Steinberg GR, Dyck JR. AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovascular Research 2015, 107: 235-245. PMID: 26023060, PMCID: PMC4565988, DOI: 10.1093/cvr/cvv166.Peer-Reviewed Original ResearchConceptsHeart failureCardiac functionCardiac hypertrophyRole of AMPKAMPK deficiencyCompensatory cardiac hypertrophyWild-type littermatesFatty acid oxidation ratesMyocardial energy metabolismAlters cardiac functionMuscle-specific deletionFirst mouse modelDiastolic functionAbsence of changesCardiac dysfunctionWT miceBasal glucoseMyocardial functionMyocardial metabolismCell shorteningMouse modelCardiac muscle resultsHypertrophyImpaired activationTroponin I
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