2022
Super‐killer CTLs are generated by single gene deletion of Bach2
Barton P, Davenport A, Hukelmann J, Cantrell D, Stinchcombe J, Richard A, Griffiths G. Super‐killer CTLs are generated by single gene deletion of Bach2. European Journal Of Immunology 2022, 52: 1776-1788. PMID: 36086884, PMCID: PMC9828676, DOI: 10.1002/eji.202249797.Peer-Reviewed Original ResearchConceptsCD8<sup>+</sup> T cellsT cellsEffector CTLSplenic CD8<sup>+</sup> T cellsT cell-mediated immune regulationMurine CD8<sup>+</sup> T cellsCentral memory T cellsWild-type CTLMemory T cellsNaive T cellsGene deletionAbsence of Bach2In vitro activityCytolytic capacityBach2 deficiencyNaive cellsEnhanced cytotoxicityImmune regulationCytolytic granulesCytotoxic advantageCTLBach2Wild-typeDifferentiation stateGranule contents
2013
The plasticity of human Treg and Th17 cells and its role in autoimmunity
Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars In Immunology 2013, 25: 305-312. PMID: 24211039, PMCID: PMC3905679, DOI: 10.1016/j.smim.2013.10.009.Peer-Reviewed Original ResearchConceptsTh17 cellsT cellsMultiple sclerosisAutoimmune diseasesImmune systemPlasticity of TregsEffector T cellsRegulatory T cellsEffector cell populationsHuman autoimmune diseasesT cell subpopulationsT helper cellsParticular multiple sclerosisT cell plasticityHigh gradeInnate immune systemAdaptive immune systemStrength of stimulationT cell developmentHuman TregsHelper cellsImmune responseImmune reactionsNaive cellsTregs
2010
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets
Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets. The Journal Of Immunology 2010, 185: 7146-7150. PMID: 21078902, PMCID: PMC3133669, DOI: 10.4049/jimmunol.1002163.Peer-Reviewed Original ResearchTGF-β Induces IL-9 Production from Human Th17 Cells
Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-β Induces IL-9 Production from Human Th17 Cells. The Journal Of Immunology 2010, 185: 46-54. PMID: 20498357, PMCID: PMC2936106, DOI: 10.4049/jimmunol.1000356.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell PolarityCells, CulturedCoculture TechniquesDiabetes Mellitus, Type 1Gene Expression RegulationHumansImmunohistochemistryInflammation MediatorsInterleukin-17Interleukin-9Middle AgedResting Phase, Cell CycleT-Lymphocytes, Helper-InducerTransforming Growth Factor beta1Young AdultConceptsCD4 T cellsIL-9 productionIL-17IL-9IL-1betaCD4 cellsProinflammatory cytokinesT cellsNaive cellsIL-9/ILCD4 T cell subsetsMemory CD4 T cellsNaive CD4 T cellsHuman naive CD4 T cellsTh17-inducing cytokinesT cell subsetsHuman autoimmune diseasesAutoimmune diabetesMemory CD4Th17 cellsTh2 cytokinesAutoimmune diseasesCell subsetsIL-4Inflammatory conditions
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