Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling
Ng S, Bahig H, Wang J, Cardenas C, Lucci A, Hall C, Meas S, Sarli V, Yuan Y, Urbauer D, Ding Y, Ikner S, Dinh V, Elgohari B, Johnson J, Skinner H, Gunn G, Garden A, Phan J, Rosenthal D, Morrison W, Frank S, Hutcheson K, Mohamed A, Lai S, Ferrarotto R, MacManus M, Fuller C. Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling. BMC Cancer 2018, 18: 903. PMID: 30231854, PMCID: PMC6148797, DOI: 10.1186/s12885-018-4808-5.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersClinical ProtocolsFemaleHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLiquid BiopsyMagnetic Resonance ImagingMaleNeoplastic Cells, CirculatingPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisProspective StudiesTreatment OutcomeConceptsNeck cancerPET/CT imagesTreatment responseBlood samplesTumor cellsTumor cell measurementUtility of CTCsProspective observational studyBackgroundMagnetic resonance imagingSoft tissue involvementDate of enrollmentSerial MR imagingDe-escalation strategiesPersonalization of treatmentEDTA blood samplesCirculating Tumor CellsCTC assessmentMucosal headClinical outcomesDose escalationImaging changesLocal therapyPretreatment CTPatient selectionPrognostic valueExtracapsular extension is not a significant prognostic indicator in non-squamous cancers of the major salivary glands
Cheraghlou S, Yu PK, Otremba MD, Mehra S, Yarbrough WG, Judson BL. Extracapsular extension is not a significant prognostic indicator in non-squamous cancers of the major salivary glands. Cancers Of The Head & Neck 2018, 3: 5. PMID: 31093358, PMCID: PMC6460801, DOI: 10.1186/s41199-018-0032-x.Peer-Reviewed Original ResearchSignificant prognostic indicatorPrognostic indicatorMajor salivary glandsAdverse featuresSalivary cancerPrognostic valueECE statusUnivariate Kaplan-Meier analysisAdditional adverse featuresCox survival regressionNode-positive cancersNon-squamous cancersPost-operative radiotherapyHigh-risk featuresSalivary glandsPositive surgical marginsKaplan-Meier analysisSquamous cell cancerSalivary gland cancerSCC patientsMucosal headWorse survivalImproved survivalSurgical marginsCell cancer
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