Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing
Park D, Jiang S, Tadie J, Stigler W, Gao Y, Deshane J, Abraham E, Zmijewski J. Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing. Molecular Medicine 2013, 19: 387-398. PMID: 24091934, PMCID: PMC3883969, DOI: 10.2119/molmed.2013.00065.Peer-Reviewed Original ResearchMeSH KeywordsActinsAminoimidazole CarboxamideAMP-Activated Protein KinasesAnimalsBacteremiaChemotaxis, LeukocyteEnzyme ActivationHeterocyclic Compounds, 3-RingHL-60 CellsHumansMaleMetforminMiceMice, Inbred C57BLNeutrophilsPeritonitisPhagocytosisPhosphorylationProtein Kinase InhibitorsPyridinesRibonucleotidesRNA, Small InterferingSignal TransductionSirolimusConceptsAdenosine monophosphate-activated protein kinaseAminoimidazole carboxamide ribonucleotideActivation of adenosine monophosphate-activated protein kinaseTreatment of neutrophilsAdenosine monophosphate-activated protein kinase activationBacterial killingSmall interfering RNA (siRNA)-mediated knockdownBlockade of AMPK activationAdenosine monophosphate-activated protein kinase inhibitor Compound CIkBa degradationMonophosphate-activated protein kinaseInhibitor compound CDownstream signaling eventsLPS/Toll-like receptor 4Inhibition of chemotaxisActin polymerizationAMPK activationAMPK phosphorylationCompound CSignaling eventsProtein kinaseInability of neutrophilsNeutrophil motilityAssociated with severe infectionsInvading microorganisms
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