2025
Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy
Zhou F, Lian W, Yuan X, Wang Z, Xia C, Yan Y, Wang W, Tong Z, Cheng Y, Xu J, He J, Zhang W. Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy. Alzheimer's Research & Therapy 2025, 17: 47. PMID: 39972387, PMCID: PMC11837312, DOI: 10.1186/s13195-025-01695-w.Peer-Reviewed Original ResearchConceptsMitochondrial functionMitochondrial membrane potential depolarizationNLRP3 inflammasome activationInflammasome activationAlzheimer's diseasePromotion of mitophagyAnti-AD candidateBNIP3 pathwayFormation of autophagosomesDamaged mitochondriaProgressive neurodegenerative disorderProduction of ROSMitophagy fluxOxidative phosphorylationMitophagyMembrane potential depolarizationPINK1/Parkin signalingIncreased colocalizationMitochondrial dysfunctionNLRP3 inflammasomeAD miceSynaptic damageEt ZuccCaspase-1Neurodegenerative disorders
2023
Apolipoproteins L1 and L3 control mitochondrial membrane dynamics
Lecordier L, Heo P, Graversen J, Hennig D, Skytthe M, d’Elzius A, Pincet F, Pérez-Morga D, Pays E. Apolipoproteins L1 and L3 control mitochondrial membrane dynamics. Cell Reports 2023, 42: 113528. PMID: 38041817, PMCID: PMC10765320, DOI: 10.1016/j.celrep.2023.113528.Peer-Reviewed Original ResearchConceptsVesicle-associated membrane protein 8Mitochondrial membrane dynamicsPI4KBMembrane dynamicsPI4KB activityMembrane protein 8Mitochondrial reactive oxygen speciesNeuronal calcium sensor-1Apolipoprotein L1C-terminal truncationsEndolysosomal membranesFission factorCalneuron-1Mitochondria fissionProhibitin 2Reactive oxygen speciesMitophagy fluxProtein 8APOL3KbOxygen speciesGolgiKB activityAPOL1Mitophagy
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