Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson M, Janjigian Y, O’Reilly E, Segal N, Saltz L, Reidy-Lagunes D, Varghese A, Bajorin D, Carlo M, Cadoo K, Walsh M, Weiser M, Aguilar J, Klimstra D, Diaz L, Baselga J, Zhang L, Ladanyi M, Hyman D, Solit D, Robson M, Taylor B, Offit K, Berger M, Stadler Z. Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer. Journal Of Clinical Oncology 2018, 37: 286-295. PMID: 30376427, PMCID: PMC6553803, DOI: 10.1200/jco.18.00283.Peer-Reviewed Original ResearchConceptsGenetic testing criteriaPrevalence of LSFamily cancer historyMicrosatellite instabilityMSI-HMismatch repair genesMMR-D tumorsMicrosatellite instability statusHigh-frequency microsatellite instabilityPrediction of LSLynch syndromeMMR-DCancer historyCancer surveillanceEndometrial cancerPersonal/family historyUnique patientsMismatch repair deficiencyPreventive measuresCancer predispositionSolid tumorsAffected familiesTumor spectrumImmunohistochemical stainingRepair genes
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