2007
Legionella pneumophila proteins that regulate Rab1 membrane cycling
Ingmundson A, Delprato A, Lambright DG, Roy CR. Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 2007, 450: 365-369. PMID: 17952054, DOI: 10.1038/nature06336.Peer-Reviewed Original ResearchConceptsDrrA proteinRab1 functionMembrane cyclingGTPase-activating protein activityIntracellular pathogen Legionella pneumophilaRecruitment of Rab1Pathogen-occupied vacuolesPathogen Legionella pneumophilaDistinct biochemical reactionsL. pneumophilaLegionella pneumophilaRab1 activityRab1 activationRab proteinsEukaryotic cellsExchange factorGTP hydrolysisProtein activityRab1Membrane functionBacterial replicationProteinBiochemical reactionsPneumophilaVacuoles
2006
In Vivo Membrane Topology of Escherichia coli SecA ATPase Reveals Extensive Periplasmic Exposure of Multiple Functionally Important Domains Clustering on One Face of SecA*
Jilaveanu LB, Oliver DB. In Vivo Membrane Topology of Escherichia coli SecA ATPase Reveals Extensive Periplasmic Exposure of Multiple Functionally Important Domains Clustering on One Face of SecA*. Journal Of Biological Chemistry 2006, 282: 4661-4668. PMID: 17166834, DOI: 10.1074/jbc.m610828200.Peer-Reviewed Original ResearchConceptsSecA ATPaseEscherichia coli SecA ATPaseProtein translocation pathwayProtein-conducting channelRegion of SecABacterial plasma membraneMembrane-integrated stateTransport of proteinsSecA mutantSecA domainProtein translocationMembrane topologyMembrane cyclingSecA structureMembrane insertionTranslocation pathwayProtein cargoPlasma membraneSulfhydryl labelingN-domainSecAC-domainTrans sideChannel complexLabeling patterns
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