2025
Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies
Munshi M, Kahkoska A, Neumiller J, Alexopoulos A, Allen N, Cukierman-Yaffe T, Huang E, Lee S, Lipska K, McCarthy L, Meneilly G, Pandya N, Pratley R, Rodriguez-Mañas L, Sinclair A, Sy S, Toschi E, Weinstock R. Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies. The Lancet Diabetes & Endocrinology 2025, 13: 427-437. PMID: 39978368, PMCID: PMC12178675, DOI: 10.1016/s2213-8587(24)00372-3.Peer-Reviewed Original ResearchOlder adultsCare of older individualsHigh-risk medicationsTreating older peopleClinical practice gapsInterfere with patients' abilityReduce medication burdenDiabetes treatment regimensImprove carePatient's current needsSelf-CareDe-prescribingDiabetes guidelinesDeprescribing strategiesSimplification of regimensOlder peoplePractice gapType 2 diabetesDeprescribingPatient's abilityMultiple medical comorbiditiesDiabetes regimensOlder individualsDiabetes SocietyMedical burden
2024
Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptoms
2022
Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda
Lee Y, Ssekalo I, Kazungu R, Blackwell T, Muwereza P, Wu Y, Sáenz J. Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda. Heliyon 2022, 8: e12612. PMID: 36593846, PMCID: PMC9803786, DOI: 10.1016/j.heliyon.2022.e12612.Peer-Reviewed Original ResearchStandard triple therapyTriple therapyChronic dyspepsiaPopulation-based screeningIndependent predictorsEradication failureStudy populationSignificant medical burdenSeverity of dyspepsiaGeneral adult populationLogistic regression analysisEastern UgandaDyspepsia QuestionnaireAntigen testingClinical suspicionMedication adherenceCommunity prevalencePositive participantsMedical burdenStool samplesDyspepsiaAdult populationHelicobacter pyloriTherapyInfection
2019
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature 2019, 569: 236-240. PMID: 31043745, PMCID: PMC6716525, DOI: 10.1038/s41586-019-1167-6.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsChronic inflammationDestabilization of plaquesGlobal medical burdenImportant pathophysiological contributorCell deathPerpetuation of inflammationChronic vascular diseaseNeutrophil extracellular trapsMajor underlying causeLytic cell deathPathophysiological contributorVascular diseaseMedical burdenExtracellular trapsMouse modelAtherosclerotic lesionsMolecular mediatorsInflammationTissue damageTherapeutic valueMuscle cellsUnderlying causeDeathHistone H4
2018
Insomnia in Community‐Living Persons with Advanced Age
Miner B, Gill TM, Yaggi HK, Redeker NS, Van Ness PH, Han L, Fragoso CAV. Insomnia in Community‐Living Persons with Advanced Age. Journal Of The American Geriatrics Society 2018, 66: 1592-1597. PMID: 29785710, PMCID: PMC6167156, DOI: 10.1111/jgs.15414.Peer-Reviewed Original ResearchConceptsSelf-reported sleep-disordered breathingRestless legs syndromeInsomnia Severity IndexDepressive symptomsBaseline characteristicsOlder adultsCognitive impairmentAverage baseline characteristicsEpidemiology of insomniaChronic lung diseaseSleep-disordered breathingMultivariable regression modelsHigh medical burdenCurrent smokersLegs syndromeLung diseaseClinical correlatesDaytime sleepinessSleep disturbancesAdvanced ageMedical burdenMild severityCardiovascular diseaseDiagnostic confirmationHigh prevalence
2016
Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells
Sumbayev V, Silva I, Blackburn J, Gibbs B, Yasinska I, Garrett M, Tonevitsky A, Ushkaryov Y. Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells. Oncotarget 2016, 7: 45575-45583. PMID: 27322212, PMCID: PMC5216743, DOI: 10.18632/oncotarget.10039.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaTreatment of AMLPrimary human AML cellsHuman acute myeloid leukemia cellsAcute myeloid leukemia cellsLeukemia cellsHuman acute myeloid leukemiaHealthy leukocytesHuman AML cellsLatrophilin-1Myeloid leukemia cellsSerious medical burdenHuman monocytic leukemia cell lineMonocytic leukemia cell lineAML diagnosisSystemic diseaseMedical burdenMyeloid leukemiaAML cellsNovel biomarkersPotential new avenuesBone marrowLeukemia cell linesMalignant cellsBlood cancersPurpose in Life is Associated with a Reduced Risk of Incident Physical Disability in Aging U.S. Military Veterans
Mota NP, Tsai J, Kirwin PD, Sareen J, Southwick SM, Pietrzak RH. Purpose in Life is Associated with a Reduced Risk of Incident Physical Disability in Aging U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2016, 24: 706-714. PMID: 27160984, DOI: 10.1016/j.jagp.2016.03.004.Peer-Reviewed Original ResearchConceptsIncident IADL disabilityIncident physical disabilityIADL disabilityPhysical disabilityU.S. military veteransDaily livingGreater medical burdenIncident ADL disabilityProspective cohort studyTwo-year incidenceMilitary veteransProtective psychosocial factorsWave 1Incident disabilityCohort studyADL disabilityChronic painNational HealthMedical burdenInstrumental activitiesMedical conditionsReduced riskPsychosocial factorsU.S. veteransVeterans Study
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