Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature 2019, 569: 236-240. PMID: 31043745, PMCID: PMC6716525, DOI: 10.1038/s41586-019-1167-6.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsChronic inflammationDestabilization of plaquesGlobal medical burdenImportant pathophysiological contributorCell deathPerpetuation of inflammationChronic vascular diseaseNeutrophil extracellular trapsMajor underlying causeLytic cell deathPathophysiological contributorVascular diseaseMedical burdenExtracellular trapsMouse modelAtherosclerotic lesionsMolecular mediatorsInflammationTissue damageTherapeutic valueMuscle cellsUnderlying causeDeathHistone H4
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