2024
NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer
De La Cruz P, McAdams J, Morales Aquino M, Fernandez A, Elliott A, Lustberg M, Schorl C, Ribeiro J, James N. NF-κB associated markers of prognosis in early and metastatic triple negative breast cancer. Breast Cancer Research 2024, 26: 175. PMID: 39623404, PMCID: PMC11613493, DOI: 10.1186/s13058-024-01925-3.Peer-Reviewed Original ResearchConceptsNegative breast cancerBreast cancerAggressive subtypePrognostic markerBeta expressionMouse modelPD-1-based immunotherapyMetastatic triple negative breast cancerAggressive subtype of breast cancerBackgroundTriple negative breast cancerAssociated with tumor regressionSubtypes of breast cancerTriple negative breast cancerSyngeneic mouse modelSerum cytokine profilesMarker of prognosisPatient clinical outcomesTargeted treatment approachesMetastatic settingPD-1Tumor regressionTNBC cohortFrontline chemotherapySurvival outcomesCytokine profile
2011
Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure
Peck AR, Witkiewicz AK, Liu C, Stringer GA, Klimowicz AC, Pequignot E, Freydin B, Tran TH, Yang N, Rosenberg AL, Hooke JA, Kovatich AJ, Nevalainen MT, Shriver CD, Hyslop T, Sauter G, Rimm DL, Magliocco AM, Rui H. Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure. Journal Of Clinical Oncology 2011, 29: 2448-2458. PMID: 21576635, PMCID: PMC3675698, DOI: 10.1200/jco.2010.30.3552.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Agents, HormonalBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCohort StudiesDisease ProgressionDisease-Free SurvivalDrug Resistance, NeoplasmEstrogen Receptor ModulatorsFemaleHumansLymphatic MetastasisMiddle AgedNeoplasm ProteinsNuclear ProteinsPhosphorylationPhosphotyrosinePrognosisProtein Processing, Post-TranslationalSTAT5 Transcription FactorSurvival AnalysisTreatment FailureTumor Suppressor ProteinsYoung AdultConceptsNode-negative breast cancerCancer-specific survivalIndependent prognostic markerBreast cancerWhole tissue sectionsTherapy failurePrognostic markerTissue microarrayPathologist scoringMultivariate analysis patientsSystemic adjuvant therapyAdjuvant hormone therapyMarker of prognosisPoor clinical outcomeUseful predictive markerPredictors of responseNormal breast epitheliumTissue sectionsCohort IVAdjuvant therapyHormone therapyAnalysis patientsClinical outcomesDuctal carcinomaProspective study
2004
Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome
Moore H, Shia J, Klimstra D, Ruo L, Mazumdar M, Schwartz G, Minsky B, Saltz L, Guillem J. Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome. Annals Of Surgical Oncology 2004, 11: 955-961. PMID: 15525823, DOI: 10.1245/aso.2004.03.095.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCell Cycle ProteinsCombined Modality TherapyCyclin-Dependent Kinase Inhibitor p27Disease-Free SurvivalEnzyme InhibitorsFemaleFluorouracilHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyPrognosisRectal NeoplasmsRetrospective StudiesTumor Suppressor ProteinsConceptsRecurrence-free survivalResidual rectal cancerMarker of prognosisRectal cancerExpression of p27P27 expressionPreoperative chemoradiationPreoperative radiotherapyNegative predictor of recurrence-free survivalPredictor of recurrence-free survivalAssociated with recurrence-free survivalTreated with preoperative radiotherapyLocally Advanced Rectal CancerRefractory to standard therapyMolecular markers of prognosisPositive lymph nodesAdvanced rectal cancerMedian Follow-UpPrimary rectal cancerNegative prognostic factorKaplan-Meier methodLog-rank testTumor-node-metastasis stageLong-term outcomesTumor-node-metastasis
1995
Medical Therapy and Prognosis in Chronic Heart Failure Lessons from Clinical Trials
Ramahi T, Lee F. Medical Therapy and Prognosis in Chronic Heart Failure Lessons from Clinical Trials. Cardiology Clinics 1995, 13: 5-26. PMID: 7796432, DOI: 10.1016/s0733-8651(18)30058-4.Peer-Reviewed Original ResearchConceptsChronic heart failureLeft ventricular dysfunctionIntermediate-term improvementVentricular dysfunctionClinical trialsHeart failureLong-term improvementHemodynamic improvementLong-term effectsFunctional capacityShort-term hemodynamic improvementSystolic left ventricular dysfunctionChronic left ventricular dysfunctionACE inhibitor therapyRole of diureticsImmediate symptomatic reliefMajor clinical trialsSympathetic nervous systemMarker of prognosisGoal of therapyPure vasodilationAldosterone systemDirect vasodilatorAcute stabilizationPharmacologic therapy
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