Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome
Moore H, Shia J, Klimstra D, Ruo L, Mazumdar M, Schwartz G, Minsky B, Saltz L, Guillem J. Expression of p27 in Residual Rectal Cancer after Preoperative Chemoradiation Predicts Long-term Outcome. Annals Of Surgical Oncology 2004, 11: 955-961. PMID: 15525823, DOI: 10.1245/aso.2004.03.095.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCell Cycle ProteinsCombined Modality TherapyCyclin-Dependent Kinase Inhibitor p27Disease-Free SurvivalEnzyme InhibitorsFemaleFluorouracilHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyPrognosisRectal NeoplasmsRetrospective StudiesTumor Suppressor ProteinsConceptsRecurrence-free survivalResidual rectal cancerMarker of prognosisRectal cancerExpression of p27P27 expressionPreoperative chemoradiationPreoperative radiotherapyNegative predictor of recurrence-free survivalPredictor of recurrence-free survivalAssociated with recurrence-free survivalTreated with preoperative radiotherapyLocally Advanced Rectal CancerRefractory to standard therapyMolecular markers of prognosisPositive lymph nodesAdvanced rectal cancerMedian Follow-UpPrimary rectal cancerNegative prognostic factorKaplan-Meier methodLog-rank testTumor-node-metastasis stageLong-term outcomesTumor-node-metastasis
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