2025
Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.
Harnett N, Joshi S, Kumar P, Russell C, Dillon D, Baker J, Pizzagalli D, Kaufman M, Nickerson L, Jahanshad N, Salminen L, Thomopoulos S, Frijling J, Veltman D, Koch S, Nawijn L, van Zuiden M, Zhu Y, Li G, Ipser J, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Suarez-Jimenez B, Sun D, Hussain A, Huggins A, Jovanovic T, van Rooij S, Fani N, Hudson A, Sierk A, Manthey A, Walter H, van der Wee N, van der Werff S, Vermeiren R, Říha P, Lebois L, Rosso I, Olson E, Liberzon I, Angstadt M, Disner S, Sponheim S, Koopowitz S, Hofmann D, Qi R, Maron-Katz A, Kunch A, Xie H, El-Hage W, Berg H, Bruce S, McLaughlin K, Peverill M, Sambrook K, Ross M, Herringa R, Nitschke J, Davidson R, deRoon-Cassini T, Tomas C, Fitzgerald J, Blackford J, Olatunji B, Nelson S, Gordon E, Densmore M, Théberge J, Neufeld R, Olff M, Wang L, Stein D, Neria Y, Stevens J, Mueller S, Daniels J, Rektor I, King A, Davenport N, Straube T, Lu G, Etkin A, Wang X, Quidé Y, Lissek S, Cisler J, Grupe D, Larson C, Feola B, May G, Abdallah C, Lanius R, Thompson P, Morey R, Ressler K. Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40712699, PMCID: PMC12404044, DOI: 10.1016/j.bpsc.2025.07.005.Peer-Reviewed Original ResearchAssociated with PTSD symptomsPosttraumatic stress disorderEarly visual cortexStructural covariancePTSD symptomsNeural signaturesHuman Connectome Project Young AdultTrauma survivorsHeterogeneous sampleSample of trauma-exposedPosttraumatic stress disorder symptomsHuman Connectome Project Young Adult datasetVisual cortexMarker of vulnerabilityEarly visual regionsYoung adultsPosttrauma psychopathologyTrauma-exposedChildhood maltreatmentPTSD developmentStress disorderDepressive symptomsPrecision psychiatrySymptom-specificPerceived stress
2002
State and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission
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