2024
KS01.5.A A BRAIN CANCER CELL ATLAS REVEALS SHARED ASTROCYTE-LIKE STEM CELL STATES DRIVE INTRATUMOURAL HETEROGENEITY AND SHAPE IMMUNE DYNAMICS IN ADULT-TYPE DIFFUSE GLIOMAS
Zaman A, Muskovic W, Holton E, Pandya M, Zakanovic R, Chin V, Lam E, Yeung J, Sughrue M, Teo C, Powell J. KS01.5.A A BRAIN CANCER CELL ATLAS REVEALS SHARED ASTROCYTE-LIKE STEM CELL STATES DRIVE INTRATUMOURAL HETEROGENEITY AND SHAPE IMMUNE DYNAMICS IN ADULT-TYPE DIFFUSE GLIOMAS. Neuro-Oncology 2024, 26: v3-v3. PMCID: PMC11485529, DOI: 10.1093/neuonc/noae144.007.Peer-Reviewed Original ResearchAdult-type diffuse gliomasGlioma stem cellsGlioma heterogeneityGlioma subtypesImmune landscapeDiffuse gliomasT cellsStem cellsTransform treatment strategiesMyeloid cell infiltrationT cell dysfunctionIDH-mutant gliomasMalignant cell populationMalignant cell statesAdult neural stem cellsCell statesPhylogeny-based approachNeural stem cellsSingle surgeryTargeted therapyMyeloid cellsIntratumour heterogeneityCell infiltrationPARD6GTreatment strategies
2012
Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma
Tomasson M, Shen D, Hucthagowder V, Schierding W, Mullins C, Fiala M, Hall I, Wallis J, Fulton R, Fulton L, Kulkarni S, Mardis E, Wilson R, Ley T, DiPersio J, Maher C, Vij R, Ding L. Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma. Blood 2012, 120: 320. DOI: 10.1182/blood.v120.21.320.320.Peer-Reviewed Original ResearchMultiple myelomaMM patientsPeripheral bloodNormal controlsB cellsTumor cellsImportant clinical correlationsWhole-genome sequencingAbnormal B cellsSingle nucleotide variantsSodium-activated potassium channelsCommon driver mutationsPlasma B cellsChromosomal translocationsMalignant cell populationNon-hyperdiploid multiple myelomaIncurable malignancyClinical correlationWG casesPatientsEarly genetic eventsDisease pathogenesisNovel translocationDriver mutationsPotassium channels
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