2014
Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals
Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, Tsang JS, Li Y, Fauci AS. Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. Journal Of Clinical Investigation 2014, 124: 3252-3262. PMID: 24892810, PMCID: PMC4071400, DOI: 10.1172/jci74351.Peer-Reviewed Original ResearchConceptsHIV-specific responsesMemory B cellsB cellsInfected individualsMemory subsetsUninfected individualsVirus-specific B cell responsesMemory B cell subsetsPeripheral blood B cellsCertain infected individualsHIV-specific antibodiesB cell abnormalitiesAbnormal B cellsB-cell dysfunctionB cell responsesBlood B cellsB cell subsetsStage of infectionPlasma viremiaAntiretroviral therapyHIV antibodiesHIV diseaseHIV infectionImmune activationCell subsets
2012
Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma
Tomasson M, Shen D, Hucthagowder V, Schierding W, Mullins C, Fiala M, Hall I, Wallis J, Fulton R, Fulton L, Kulkarni S, Mardis E, Wilson R, Ley T, DiPersio J, Maher C, Vij R, Ding L. Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma. Blood 2012, 120: 320. DOI: 10.1182/blood.v120.21.320.320.Peer-Reviewed Original ResearchMultiple myelomaMM patientsPeripheral bloodNormal controlsB cellsTumor cellsImportant clinical correlationsWhole-genome sequencingAbnormal B cellsSingle nucleotide variantsSodium-activated potassium channelsCommon driver mutationsPlasma B cellsChromosomal translocationsMalignant cell populationNon-hyperdiploid multiple myelomaIncurable malignancyClinical correlationWG casesPatientsEarly genetic eventsDisease pathogenesisNovel translocationDriver mutationsPotassium channels
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