2014
Immunohistochemical detection of ARID1A in colorectal carcinoma: loss of staining is associated with sporadic microsatellite unstable tumors with medullary histology and high TNM stage
Ye J, Zhou Y, Weiser M, Gönen M, Zhang L, Samdani T, Bacares R, DeLair D, Ivelja S, Vakiani E, Klimstra D, Soslow R, Shia J. Immunohistochemical detection of ARID1A in colorectal carcinoma: loss of staining is associated with sporadic microsatellite unstable tumors with medullary histology and high TNM stage. Human Pathology 2014, 45: 2430-2436. PMID: 25311944, DOI: 10.1016/j.humpath.2014.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overCarcinoma, MedullaryColorectal NeoplasmsDNA MethylationDNA Mismatch RepairDNA-Binding ProteinsFemaleHumansImmunohistochemistryMaleMicrosatellite InstabilityMiddle AgedMutL Protein Homolog 1Neoplasm StagingNuclear ProteinsPilot ProjectsPromoter Regions, GeneticTranscription FactorsYoung AdultConceptsMicrosatellite unstable colorectal carcinomasLynch syndrome screeningMMR-deficient casesMedullary histologyMismatch repairMMR-deficient tumorsColorectal carcinomaDNA mismatch repairSyndrome screeningOlder agePilot studyAssociationARID1A lossOvarian cancerLoss of stainingIncreased rateConsecutive seriesMicrosatellite unstable tumorsChromatin remodeling genesMLH1Lynch
2011
Immunohistochemical Staining for DNA Mismatch Repair Proteins in Intestinal Tract Carcinoma
Shia J, Stadler Z, Weiser M, Rentz M, Gonen M, Tang L, Vakiani E, Katabi N, Xiong X, Markowitz A, Shike M, Guillem J, Klimstra D. Immunohistochemical Staining for DNA Mismatch Repair Proteins in Intestinal Tract Carcinoma. The American Journal Of Surgical Pathology 2011, 35: 447-454. PMID: 21297438, DOI: 10.1097/pas.0b013e31820a091d.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdenosine TriphosphatasesAdultAgedAged, 80 and overBiomarkers, TumorBiopsyColorectal NeoplasmsDNA Mismatch RepairDNA Repair EnzymesDNA-Binding ProteinsFemaleGerm-Line MutationHumansImmunohistochemistryMaleMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsReproducibility of ResultsConceptsMismatch repair protein abnormalitiesLynch syndromeResected specimenMismatch repair proteinsPathogenic germline mutationsWeak stainingBiopsy samplesStaining patternMLH1 stainingMSH6 stainingModerate intensityProtein abnormalitiesCancer resection specimensGastrointestinal tract cancerMismatch repair abnormalitiesImmunohistochemical staining patternsConcordant staining patternSpecimens of adenocarcinomaColorectal cancerIncreased riskMSH6Loss of stainingMLH1Rectal carcinomaGermline mutations
2008
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma
Choi YJ, Pinto M, Hao L, Riba A. Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. Modern Pathology 2008, 21: 1224-1237. PMID: 18587329, DOI: 10.1038/modpathol.2008.106.Peer-Reviewed Original ResearchConceptsE-cadherin stainingLobular carcinomaLobular neoplasiaDuct lesionsDuct carcinomaPrevious diagnosisBreast lesionsMorphologic diagnosisInterobserver variabilityDifferent antibodiesE-cadherinImportant therapeutic implicationsParaffin-embedded sectionsLoss of stainingE-cadherin staining patternDuctal neoplasiaDuctal lesionsHistologic featuresLobular lesionsHistology diagnosisSurgical pathologistsImmunohistochemistry techniquesTherapeutic implicationsBlinded mannerCarcinoma
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply