mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
Kaartinen M, Griffiths G, Markham A, Milstein C. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification. Nature 1983, 304: 320-324. PMID: 6877353, DOI: 10.1038/304320a0.Peer-Reviewed Original ResearchConceptsAnti-oxazolone antibodiesHeavy chain mRNAEarly diversificationSynthetic primersD-JHMRNA sequencesChain mRNASequenceMRNARestricted heterogeneityPrimersAnti-oxazolone hybridomas and the structure of the oxazolone idiotype.
Kaartinen M, Griffiths G, Hamlyn P, Markham A, Karjalainen K, Pelkonen J, Mäkelä O, Milstein C. Anti-oxazolone hybridomas and the structure of the oxazolone idiotype. The Journal Of Immunology 1983, 130: 937-45. PMID: 6401310, DOI: 10.4049/jimmunol.130.2.937.Peer-Reviewed Original ResearchConceptsLight chain mRNAMethod of DNA sequencingAnti-oxazolone antibodiesH chain mRNAAntibody-secreting hybridoma clonesAmino acid sequenceChain mRNALight (L) chainsHapten 2-phenyloxazoloneNucleotide differencesProtein sequencesLabeled deoxynucleotidesAcid sequenceDNA sequencesCrude mRNAHeavy (HSynthetic oligonucleotidesHypervariable regionMRNA preparationsD segmentsHybridoma clonesConstant regionSequencePrimersMRNA
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