2023
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
Cyranka L, Mariegaard I, Skjødt M, Bayarri-Olmos R, Mollnes T, Garred P, Rosbjerg A. Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody. Journal Of Innate Immunity 2023, 15: 836-849. PMID: 37952515, PMCID: PMC10691831, DOI: 10.1159/000535084.Peer-Reviewed Original ResearchConceptsC5a receptor 1C5aR1 inhibitionPolymorphonuclear leukocytesComplement C5a receptor 1Receptor 1Monoclonal antibodiesWhole bloodActivation markers CD11bIsolated polymorphonuclear leukocytesPotential therapeutic candidateInflammatory disease treatmentWhole blood modelCalcium flux assaysCell-binding studiesMouse monoclonal antibodyC5a-C5aR1Marker CD11bTherapeutic candidateHuman whole bloodC5aCalcium fluxComplement systemC5aR1Hybridoma clonesDisease treatment
1983
Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.
Kaartinen M, Griffiths G, Hamlyn P, Markham A, Karjalainen K, Pelkonen J, Mäkelä O, Milstein C. Anti-oxazolone hybridomas and the structure of the oxazolone idiotype. The Journal Of Immunology 1983, 130: 937-45. PMID: 6401310, DOI: 10.4049/jimmunol.130.2.937.Peer-Reviewed Original ResearchConceptsLight chain mRNAMethod of DNA sequencingAnti-oxazolone antibodiesH chain mRNAAntibody-secreting hybridoma clonesAmino acid sequenceChain mRNALight (L) chainsHapten 2-phenyloxazoloneNucleotide differencesProtein sequencesLabeled deoxynucleotidesAcid sequenceDNA sequencesCrude mRNAHeavy (HSynthetic oligonucleotidesHypervariable regionMRNA preparationsD segmentsHybridoma clonesConstant regionSequencePrimersMRNA
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