2024
Energy partitioning in the cell cortex
Chen S, Seara D, Michaud A, Kim S, Bement W, Murrell M. Energy partitioning in the cell cortex. Nature Physics 2024, 20: 1824-1832. DOI: 10.1038/s41567-024-02626-6.Peer-Reviewed Original ResearchCell cortexEntropy production rateGAP expressionCortical actin filamentsRho GTPase pathwayGTPase pathwayMyosin IIActin filamentsDiversity patternsEnergy partitioningRhoOnsager reciprocityCell phenotypeProtein expressionThermodynamic equilibriumCellsSpiral travelling waveProduction rateTemporal dynamicsLiving systemsActinEnergyWavePhenotypeActivity
2022
Two-photon fluorescent probes for quantitative bio-imaging analysis in live tissues
Juvekar V, Lee H, Lee D, Kim H. Two-photon fluorescent probes for quantitative bio-imaging analysis in live tissues. TrAC Trends In Analytical Chemistry 2022, 157: 116787. DOI: 10.1016/j.trac.2022.116787.Peer-Reviewed Original ResearchFluorescent probeTwo-photon fluorescent probeDeep tissue imagingNeutral moleculesLow-energy lightTP fluorescent probesExcitation sourceHigh-resolution fluorescence imagingBio-thiolsTarget analytesMetal ionsEnergy lightReactive speciesMillimeter depthLight scatteringNear-infrared windowLiving systemsScatteringDesign strategyProbe design strategyExcitationTP probesAnalytesProbeBio-imaging analysis
2021
Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues
Juvekar V, Lee H, Kim H. Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues. ACS Applied Bio Materials 2021, 4: 2957-2973. PMID: 35014386, DOI: 10.1021/acsabm.1c00063.Peer-Reviewed Original ResearchConceptsEnzyme activityDetectable enzyme activityEnzymatic probesEnzyme regulationBiological significanceEfficient detection toolAbnormal enzyme activityEnzymeAlzheimer's diseasePhysiological functionsLiving organismsTwo-photon microscopyProbe developmentBiological systemsEnzyme sensorEnzyme investigationsMinimal perturbationFluorescent probeLiving systemsReal-time bioimagingBiosynthesesTwo-photon fluorescent probeActivityDetection toolsLiving tissues
2018
Subcellular Organization: A Critical Feature of Bacterial Cell Replication
Surovtsev IV, Jacobs-Wagner C. Subcellular Organization: A Critical Feature of Bacterial Cell Replication. Cell 2018, 172: 1271-1293. PMID: 29522747, PMCID: PMC5870143, DOI: 10.1016/j.cell.2018.01.014.Peer-Reviewed Original ResearchConceptsSelf-replicating entitiesCellular lifeStructured genomesDynamic spatial patternsChallenge cellsIntracellular organellesCellular replicationCytoskeletal filamentsBacterial cellsUnique biological propertiesComplex internal organizationSpatial organizationSmall formsCell replicationActive transportLiving systemsBacteriaReplicationGenomeBiological propertiesCellsSpatial patternsOrganellesPowerful meansHallmark
2014
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation
Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. The EMBO Journal 2014, 33: 981-993. PMID: 24705786, PMCID: PMC4193932, DOI: 10.1002/embj.201488411.Peer-Reviewed Original Research
2012
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress. Free Radical Biology And Medicine 2012, 56: 89-101. PMID: 23195683, PMCID: PMC3631350, DOI: 10.1016/j.freeradbiomed.2012.11.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive oxygen speciesOxidative stressMulticellular speciesEukaryotic organismsElectrophilic stressExogenous aldehydesCancer stem cellsLiving systemsStress responseCellular responsesEnvironmental stressorsSimilar functionsAldehyde scavengerSpeciesStem cellsLipid peroxidationROS loadOxygen speciesElevated oxidative stressLipid membranesALDHALDH expressionOrganismsPathological processesPathological conditionsModeling cellular signaling: taking space into the computation
Sneddon MW, Emonet T. Modeling cellular signaling: taking space into the computation. Nature Methods 2012, 9: 239-242. PMID: 22373909, PMCID: PMC4713026, DOI: 10.1038/nmeth.1900.Peer-Reviewed Original Research
2001
In Vitro Selection of Kinase and Ligase Deoxyribozymes
Li Y, Breaker R. In Vitro Selection of Kinase and Ligase Deoxyribozymes. Methods 2001, 23: 179-190. PMID: 11181037, DOI: 10.1006/meth.2000.1119.Peer-Reviewed Original ResearchConceptsDNA ligationModern living systemsDNA kinaseEnzymatic functionRandom sequence populationVitro SelectionProtein enzymesConstruction of DNADNA constructsDNA phosphorylationDNADeoxyribozymesKinaseLiving systemsFundamental roleChemical reactionsAdenylationFundamental questionsBiocatalysisPhosphorylationEnzymeBiotechnologySelection strategyDiscoveryDetailed overview
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