2013
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Li Y, Wong K, Giles A, Jiang J, Lee J, Adams A, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Gastroenterology 2013, 146: 539-549.e7. PMID: 24184811, PMCID: PMC4228483, DOI: 10.1053/j.gastro.2013.10.059.Peer-Reviewed Original ResearchConceptsControl miceLivers of control miceFibroblast growth factor 21White adipose tissueHepatic overexpressionCirculating LevelsExpression of genesHepatic steatosisEnergy expenditureHormone-like regulatorsLKO miceFasted control miceHepatic expressionAbstractText Label="Background &Late-onset obesityAdipose tissueWild-type littermatesFatty acid oxidationNormal chow dietReal-time polymerase chain reaction assayControl energy balanceHormone fibroblast growth factor 21Severe hepatic steatosisFasting-induced steatosisLevels of FGF21
2005
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
Dong X, Park S, Lin X, Copps K, Yi X, White M. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. Journal Of Clinical Investigation 2005, 116: 101-114. PMID: 16374520, PMCID: PMC1319221, DOI: 10.1172/jci25735.Peer-Reviewed Original ResearchConceptsSystemic growthHundreds of genesInsulin receptor substrateHepatic nutrient homeostasisHepatic glucose homeostasisHeterologous pathwaysNutrient homeostasisReceptor substrateGene expressionGSK3beta phosphorylationReceptor signalsHepatic gene expressionLKO miceInsulin receptorGlucose homeostasisIRS2IRS1Hepatic genesHepatic insulin receptorAkt-FoxO1 pathwayHomeostasisGenesHepatic glycogen storesLKO liversPathway
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