Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Li Y, Wong K, Giles A, Jiang J, Lee J, Adams A, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Gastroenterology 2013, 146: 539-549.e7. PMID: 24184811, PMCID: PMC4228483, DOI: 10.1053/j.gastro.2013.10.059.Peer-Reviewed Original ResearchConceptsControl miceLivers of control miceFibroblast growth factor 21White adipose tissueHepatic overexpressionCirculating LevelsExpression of genesHepatic steatosisEnergy expenditureHormone-like regulatorsLKO miceFasted control miceHepatic expressionAbstractText Label="Background &Late-onset obesityAdipose tissueWild-type littermatesFatty acid oxidationNormal chow dietReal-time polymerase chain reaction assayControl energy balanceHormone fibroblast growth factor 21Severe hepatic steatosisFasting-induced steatosisLevels of FGF21
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