T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs
Ehlers C, Biermann H, Thiele T, Schupp J, Villa M, Jänke C, Risser L, Witte T, Kalinke U, Seeliger B, Graalmann T. T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs. Rheumatology 2025, 64: 4806-4815. PMID: 40244816, DOI: 10.1093/rheumatology/keaf198.Peer-Reviewed Original ResearchInterstitial lung diseaseCD8+ T cellsT cells of patientsBronchoalveolar lavage of patientsSystemic sclerosisBronchoalveolar lavageT cellsSjogren's diseaseHealthy controlsBlood CD8+ T cellsBlood T cells of patientsLevels of HLA-DRIncreased expression of CD25Involvement of T cellsExpression of CD25Increased CD4+T cell responsesT cell receptor engagementLungs of patientsT cell characterizationExpressed increased levelsCell type 2Aberrant metabolic stateExpressed significant levelsSpectral flow cytometry
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply