2024
Sodium-Glucose Cotransporter-2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis
Patel S, Kang Y, Im K, Neuen B, Anker S, Bhatt D, Butler J, Cherney D, Claggett B, Fletcher R, Herrington W, Inzucchi S, Jardine M, Mahaffey K, McGuire D, McMurray J, Neal B, Packer M, Perkovic V, Solomon S, Staplin N, Vaduganathan M, Wanner C, Wheeler D, Zannad F, Zhao Y, Heerspink H, Sabatine M, Wiviott S. Sodium-Glucose Cotransporter-2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis. Circulation 2024, 149: 1789-1801. PMID: 38583093, PMCID: PMC11149938, DOI: 10.1161/circulationaha.124.069568.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter-2 inhibitorsSudden cardiac deathAtherosclerotic cardiovascular diseaseCardiovascular deathPatient populationHF deathCardiac deathReduction of cardiovascular deathTrial-level meta-analysisMyocardial infarctionCardiovascular diseaseOverall populationCotransporter-2 inhibitorsRisk of MACETrial of patientsRate of MACEIndividual components of MACEAdverse cardiovascular eventsKidney-related outcomesAll-Cause MortalityChronic kidney diseaseComponents of MACESGLT2i therapyPlacebo-ControlledClinical characteristics
2012
Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis
Coca SG, Ismail-Beigi F, Haq N, Krumholz HM, Parikh CR. Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis. JAMA Internal Medicine 2012, 172: 761-769. PMID: 22636820, PMCID: PMC3688081, DOI: 10.1001/archinternmed.2011.2230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood GlucoseDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlycated HemoglobinHumansHypoglycemic AgentsKidney Failure, ChronicKidney Function TestsMaleMiddle AgedMonitoring, PhysiologicPrognosisRandomized Controlled Trials as TopicRenal DialysisRisk AssessmentSeverity of Illness IndexConceptsIntensive glucose controlRenal end pointsSerum creatinine levelsConventional glucose controlGlucose controlType 2 diabetesRenal diseaseCreatinine levelsEnd pointGlycemic controlSystematic reviewType 2 diabetes mellitusAggressive glycemic controlClinical renal outcomesKidney-related outcomesIntensive glycemic controlRenal outcomesCumulative incidenceDiabetes mellitusRandomized trialsConventional therapyLanguage restrictionsMacroalbuminuriaMicroalbuminuriaType 2
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