2020
ERICH3: vesicular association and antidepressant treatment response
Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim D, Liu E, Nguyen T, Biernacka J, Kaddurah-Daouk R, Dunlop B, Craighead W, Mayberg H, Binder E, Frye M, Wang L, Weinshilboum R. ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry 2020, 26: 2415-2428. PMID: 33230203, PMCID: PMC8141066, DOI: 10.1038/s41380-020-00940-y.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with SSRI responseGenome-wide association studiesSSRI treatment outcomeAntidepressant treatment responseVesicular functionSerotonin reuptake inhibitorsClathrin heavy chainHuman iPSC-derived neuronsPlasma 5-HT concentrationsVesicle-like structuresSSRI responseSSRI trialMDD trialsMDD patientsDepressive disorderSSRI therapyReuptake inhibitorsGenome-wideIPSC-derived neuronsSK-N-SH cellsAssociation studiesInteracting proteinsERICH3Neuronal cell types
2017
HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus
Fusco D, Pratt H, Kandilas S, Cheon S, Lin W, Cronkite D, Basavappa M, Jeffrey K, Anselmo A, Sadreyev R, Yapp C, Shi X, O'Sullivan J, Gerszten R, Tomaru T, Yoshino S, Satoh T, Chung R. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Frontiers In Microbiology 2017, 8: 240. PMID: 28265266, PMCID: PMC5316548, DOI: 10.3389/fmicb.2017.00240.Peer-Reviewed Original ResearchChromatin immunoprecipitation-sequencingFunctional genomic screensIFN antiviral responseNuclear receptor interaction proteinIFN signal transductionAntiviral effector genesDengue virusReceptor-interacting proteinHost response to viral infectionHost IFN signalingIFN-stimulated genesResponse to viral infectionGenomic screeningEffector genesInteracting proteinsInfectious dengue virusISRE elementKnockdown cellsAnti-dengue activityCo-ImmunoprecipitationGene productsSignal transductionTranscriptional programsAntiviral effect of IFNAntiviral effectors
2014
X-Ray Structure of an Anticoagulant RNA Aptamer Bound to Factor Xa. Structural Basis for Its Ability to Disrupt Interactions Between Xa and Va within Prothrombinase
Kumar S, Sullenger B, Stayrook S, Krishnaswamy S. X-Ray Structure of an Anticoagulant RNA Aptamer Bound to Factor Xa. Structural Basis for Its Ability to Disrupt Interactions Between Xa and Va within Prothrombinase. Blood 2014, 124: 4232. DOI: 10.1182/blood.v124.21.4232.4232.Peer-Reviewed Original ResearchRNA aptamersC-terminusBinding to factor VIIIaIntrinsic XaseBase-paired stemActive site functionAssembly of prothrombinaseFactor Xa and factor VaSELEX screeningMolecular replacementInteracting proteinsProteinase domainFunctional characterizationAptamer bindingCatalytic Ser195Disrupt interactionsA-resolutionFactor XaHeparin bindingStructural basisAutolysis loopNucleotideInteracting speciesNucleotide basesSolvent accessible surface area
2008
Trim11 increases expression of dopamine β-hydroxylase gene by interacting with Phox2b
Hong S, Chae H, Lardaro T, Hong S, Kim K. Trim11 increases expression of dopamine β-hydroxylase gene by interacting with Phox2b. Biochemical And Biophysical Research Communications 2008, 368: 650-655. PMID: 18275850, PMCID: PMC2712928, DOI: 10.1016/j.bbrc.2008.01.165.Peer-Reviewed Original ResearchMeSH KeywordsCell LineCells, CulturedDNA-Binding ProteinsDopamine beta-HydroxylaseGanglia, SympatheticGene Expression Regulation, DevelopmentalHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsKidneyNeuronsProtein Interaction MappingTrans-ActivatorsTranscription FactorsTripartite Motif ProteinsUp-RegulationConceptsB30.2/SPRY domainProtein-protein interaction assaysYeast two-hybrid screenTwo-hybrid screenCoiled-coil domainHomeodomain transcription factor Phox2bExpression of TRIM11Neural crest stem cellsB-boxInteraction assaysProtein familyRING domainInteracting proteinsDopamine beta-hydroxylaseCentral nervous systemPeripheral nervous systemTripartite motifExpression of Phox2bSympathetic gangliaTRIM11Forced expressionNA phenotypeNervous systemIncreased mRNA levelsTranscription factor Phox2b
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