ERICH3: vesicular association and antidepressant treatment response
Liu D, Zhuang Y, Zhang L, Gao H, Neavin D, Carrillo-Roa T, Wang Y, Yu J, Qin S, Kim D, Liu E, Nguyen T, Biernacka J, Kaddurah-Daouk R, Dunlop B, Craighead W, Mayberg H, Binder E, Frye M, Wang L, Weinshilboum R. ERICH3: vesicular association and antidepressant treatment response. Molecular Psychiatry 2020, 26: 2415-2428. PMID: 33230203, PMCID: PMC8141066, DOI: 10.1038/s41380-020-00940-y.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with SSRI responseGenome-wide association studiesSSRI treatment outcomeAntidepressant treatment responseVesicular functionSerotonin reuptake inhibitorsClathrin heavy chainHuman iPSC-derived neuronsPlasma 5-HT concentrationsVesicle-like structuresSSRI responseSSRI trialMDD trialsMDD patientsDepressive disorderSSRI therapyReuptake inhibitorsGenome-wideIPSC-derived neuronsSK-N-SH cellsAssociation studiesInteracting proteinsERICH3Neuronal cell typesSex differences in brain gene expression among suicide completers
Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Mendoza-Morales RC, García-Dolores F, Díaz-Otañez CE, González-Sáenz EE, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Flores G, Vázquez-Roque RA, Nicolini H. Sex differences in brain gene expression among suicide completers. Journal Of Affective Disorders 2020, 267: 67-77. PMID: 32063575, DOI: 10.1016/j.jad.2020.01.167.Peer-Reviewed Original ResearchConceptsBrain gene expressionSex-specific gene expression patternsGene expressionRibonucleic protein complexesGene expression patternsGene expression profilesProtein complexesGene setsDNA bindingExpression patternsExpression profilesGenesSuicide geneBiological levelsVesicular functionCell proliferationValuable foundationDifferentiallyMicroarrayExpressionSex-specific factorsSuicide completersSuicidal brainImmune responseSex differences
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