2024
Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study
Lewis N, Harker E, Grant L, Zhu Y, Grijalva C, Chappell J, Rhoads J, Baughman A, Casey J, Blair P, Jones I, Johnson C, Lauring A, Gaglani M, Ghamande S, Columbus C, Steingrub J, Shapiro N, Duggal A, Busse L, Felzer J, Prekker M, Peltan I, Brown S, Hager D, Gong M, Mohamed A, Exline M, Khan A, Hough C, Wilson J, Mosier J, Qadir N, Chang S, Ginde A, Martinez A, Mohr N, Mallow C, Harris E, Johnson N, Srinivasan V, Gibbs K, Kwon J, Vaughn I, Ramesh M, Safdar B, Goyal A, DeLamielleure L, DeCuir J, Surie D, Dawood F, Tenforde M, Uyeki T, Garg S, Ellington S, Self W, Gaglani M, McNeal T, Calhoun S, Murthy K, Cravens J, Herrick J, McKillop A, Hoffman E, Graves A, Zayed M, Smith M, Gaglani M, Columbus C, Bychkowski A, Dunkley S, Fisher T, Grefsrud T, Hurutado-Rodriguez M, Perez G, Busse L, Lohuis C, Felzer J, Prekker M, Hendrickson A, Frosch A, Taghizadeh L, Hurreh K, O'Rourke M, Giles L, Vaughn I, Ramesh M, Lamerato L, Almawri K, Atkins I, Clark J, Lava J, McKeon C, Pinderi Z, Resk M, Koneru S, Jayaprakash R, Tirumala S, Williams K, Peltan I, Lumpkin J, Poulson S, Bassett J, Thumma V, Hager D, Ali H, Richard, Saeed S, Mohr N, Zepeski A, Nassar P, Hampton J, Fairfield C, Gibbs H, Feitsam C, Appleton I, Gong M, Mohamed A, Andrea L, Exline M, Karow S, Swoope G, So M, Pathak M, Smith D, Wilson R, Lewald Z, Snyder C, Khan M, Lee B, Rasul A, Khan A, Hernandez-Frausto A, Pocius E, Tribbett E, Briceno G, Pena J, Pellicer S, Reddy R, Allada G, Wilson J, Gordon A, Perez C, Lau L, Ferguson S, Pitre V, Tam G, Basobas L, Mosier J, Lutrick K, Hypes C, Campbell B, Ginde A, Martinez A, Steinwand A, Sullivan A, Withers C, Rademacher J, Obradovich R, Mallow C, Rivas C, Johnson N, Acidera J, Elkort K, Gajendragadkar A, McKeown M, Self W, Talbot H, Grijalva C, Blair P, Jones I, Halasa N, Chappell J, Womack K, Rhoads J, Ratcliff C, Baughman A, Johnson J, Swan S, Johnson C, Zhu Y, Rice T, Casey J, Zhu Y, Short L, Ezzell L, Whitsett M, McHenry R, Hargrave S, Luther J, Pulido C, Peterson B, Cummings S, Gauthier E, Jackson A, Rashid N, Blair M, Rice C, Kwon J, Parikh B, McDonald D, Samuels C, Vogt L, O'Neil C, Valencia A, Yerbic F, Arter O, Vu K, Safdar B, Goyal A, DeLamielleure L, Kosover M. Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study. Clinical Infectious Diseases 2024, 81: 190-197. PMID: 39607747, DOI: 10.1093/cid/ciae584.Peer-Reviewed Original ResearchDays of hospital admissionPulmonary disease severityKidney replacement therapyIn-Hospital DeathIntensive care unitDay of admissionOseltamivir treatmentVasopressor useReplacement therapyInitiation of antiviral therapyOdds of intensive care unit admissionAcute kidney replacement therapyExtrapulmonary organ failureInfluenza-positive patientsLaboratory-confirmed influenzaIntensive care unit admissionDisease severityHospital admissionMultivariate logistic regression modelSentinel Surveillance NetworkOseltamivir therapySuspected influenzaInfluenza AAntiviral therapyMultivariable proportional odds model
2020
Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate
Peaper DR, Branson B, Parwani V, Ulrich A, Shapiro MJ, Clemons C, Campbell M, Owen M, Martinello RA, Landry ML. Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate. Influenza And Other Respiratory Viruses 2020, 15: 254-261. PMID: 32851793, PMCID: PMC7902247, DOI: 10.1111/irv.12800.Peer-Reviewed Original ResearchConceptsEmergency departmentInfluenza PCRPatient managementClinical redesignED lengthInfluenza seasonED workflowPCR testingBed transfersAnti-influenza medicationsDiverse emergency departmentsHospital-acquired influenzaInfluenza-positive patientsHA influenzaNosocomial infection ratesDiagnosis of influenzaAdult emergency departmentAnti-viral therapyCommon presenting concernPost-intervention periodPre-post studyED LOSED patientsSignificant morbidityTherapeutic guidelines
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