Strategies for dealing with reactive intermediates in drug discovery and development.
Nassar A, Lopez-Anaya A. Strategies for dealing with reactive intermediates in drug discovery and development. Current Opinion In Drug Discovery & Development 2004, 7: 126-36. PMID: 14982156.Peer-Reviewed Original ResearchConceptsReactive intermediatesDrug discoveryFormation of reactive metabolitesReactive metabolitesDrug candidatesIntermediateReactionCovalent bindingDrug reactionsComplication of drug therapyIdiosyncratic drug reactionsChemical mechanismAdverse drug reactionsIn vivo systemsSafety profileImprove drug safetyDrug therapyLow incidenceClassification of adverse drug reactionsFormationDrugMetabolitesDrug safetyPotential mechanisms
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