2025
Statistical analysis of HAADF-STEM images to determine the surface coverage and distribution of immobilized molecular complexes
Jeon S, Nedzbala H, Huffman B, Pearce A, Donley C, Jia X, Bein G, Choi J, Durand N, Atallah H, Castellano F, Dempsey J, Mayer J, Hazari N, Stach E. Statistical analysis of HAADF-STEM images to determine the surface coverage and distribution of immobilized molecular complexes. Matter 2025, 8: 101919. DOI: 10.1016/j.matt.2024.11.013.Peer-Reviewed Original ResearchMolecular catalystsCatalytic systemSurface coverageImmobilization of molecular catalystsPositions of heavy atomsScanning transmission electron microscopyTransition metal complexesSurface immobilizationMetal complexesHeterogeneous catalysisHeavy atomsTransmission electron microscopyCombination of scanning transmission electron microscopyCatalystMolecular complexesSolid supportHAADF-STEM imagesElectron microscopyChemical mechanismCatalysisSurfaceAtomsComplexAttachment groupsConvolutional neural network
2018
On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation
Wang J, Liu Z, Crabtree RH, Frank J, Moore PB. On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation. Protein Science 2018, 27: 2051-2061. PMID: 30242932, PMCID: PMC6237698, DOI: 10.1002/pro.3511.Peer-Reviewed Original ResearchConceptsLocal chemical effectsElectron beamElectron radiationChemical mechanismStructure effectsChemical effectsElectron microscopeBackbone atomsChemical damageΑ-helixThermoplasma acidophilumMoleculesDose-dependent degradationQuaternary structureElectronsBeamAtomsEM mapsRadiationStructureMicroscopeResolutionSmall changesAcidophilum
2007
Chapter 8
Link K, Breaker R. Chapter 8. 2007, 134-152. DOI: 10.1039/9781847557988-00134.Peer-Reviewed Original Research
2004
Strategies for dealing with reactive intermediates in drug discovery and development.
Nassar A, Lopez-Anaya A. Strategies for dealing with reactive intermediates in drug discovery and development. Current Opinion In Drug Discovery & Development 2004, 7: 126-36. PMID: 14982156.Peer-Reviewed Original ResearchConceptsReactive intermediatesDrug discoveryFormation of reactive metabolitesReactive metabolitesDrug candidatesIntermediateReactionCovalent bindingDrug reactionsComplication of drug therapyIdiosyncratic drug reactionsChemical mechanismAdverse drug reactionsIn vivo systemsSafety profileImprove drug safetyDrug therapyLow incidenceClassification of adverse drug reactionsFormationDrugMetabolitesDrug safetyPotential mechanisms
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