2025
Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial
Lam C, Rodriguez A, Aminian A, Ferrannini E, Heerspink H, Jastreboff A, Laffin L, Pandey A, Ray K, Ridker P, Sanyal A, Yki‐Jarvinen H, Mason D, Strzelecki M, Bartee A, Cui C, Hurt K, Linetzky B, Bunck M, Nissen S. Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial. Obesity 2025 PMID: 40545827, DOI: 10.1002/oby.24332.Peer-Reviewed Original ResearchSecondary cardiovascular disease preventionCardiovascular disease preventionCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsGlucose-dependent insulinotropic polypeptide receptorPeptide-1 receptor agonistsMultiple cardiovascular risk factorsCardiovascular risk factorsHeart failure eventsNonfatal myocardial infarctionType 2 diabetesReduction of morbidityDisease preventionDouble-blindPrimary endpointReceptor agonistsClinical benefitImprove morbidityObesityCoronary revascularizationRisk factorsOutcome trialsTirzepatideMultiple outcomesSubstantial weight reduction
2023
Diagnosis and Treatment of Monogenic Hypertension in Children
Park J, Shin J. Diagnosis and Treatment of Monogenic Hypertension in Children. Yonsei Medical Journal 2023, 64: 77-86. PMID: 36719014, PMCID: PMC9892546, DOI: 10.3349/ymj.2022.0316.Peer-Reviewed Original ResearchConceptsMonogenic hypertensionBlood pressureGenetic architecture of BPResponse to antihypertensive medicationCharacteristics of early onsetGenetic architecturePositive family historyDecreased potassium levelsDysregulation of blood pressureIntravascular volume expansionCausative molecular pathwaysGenetic sequencesMortality in adulthoodLow reninRefractory hypertensionAldosterone levelsPolygenic hypertensionAntihypertensive agentsElectrolyte disordersImprove morbiditySodium reabsorptionAdrenal glandPediatric hypertensionFamily historyAntihypertensive medications
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