2018
Beyond the HPA-axis: Exploring maternal prenatal influences on birth outcomes and stress reactivity
Nazzari S, Fearon P, Rice F, Dottori N, Ciceri F, Molteni M, Frigerio A. Beyond the HPA-axis: Exploring maternal prenatal influences on birth outcomes and stress reactivity. Psychoneuroendocrinology 2018, 101: 253-262. PMID: 30497017, DOI: 10.1016/j.psyneuen.2018.11.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultalpha-AmylasesBiomarkersBirth WeightC-Reactive ProteinFemaleFetal DevelopmentFetusGestational AgeHumansHydrocortisoneHypothalamo-Hypophyseal SystemInfant, NewbornInterleukin-6Maternal ExposureMothersPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPregnancy OutcomePregnant PeoplePrenatal Exposure Delayed EffectsSalivaStress, PhysiologicalStress, PsychologicalConceptsInfant birth outcomesC-reactive proteinSelf-reported symptomsBirth outcomesHeel stickStress reactivityInterleukine-6Maternal stressEdinburgh Postnatal Depression ScaleNeonatal stress reactivityIL-6 levelsInfant cortisol responseSmaller head circumferencePostnatal Depression ScaleAntenatal maternal stressDiurnal cortisol profilesImmune response systemState-Trait Anxiety InventoryInflammatory markersAntenatal factorsHealthy newbornsHPA axisPotential confoundersPregnant womenFetal growth
2016
Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses
Gottschalk R, Martins A, Angermann B, Dutta B, Ng C, Uderhardt S, Tsang J, Fraser I, Meier-Schellersheim M, Germain R. Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. Cell Systems 2016, 2: 378-390. PMID: 27237739, PMCID: PMC4919147, DOI: 10.1016/j.cels.2016.04.016.Peer-Reviewed Original ResearchConceptsNF-κBMAPK activationInflammatory mediator productionSet of genesInnate immune response systemNF-κB signalingInnate immune systemSwitch-like mannerMacrophage functional responsesImmune response systemInflammatory mediatorsTLR4 ligandMediator productionInflammatory responseMicrobial stimuliInnate responseImmune systemMAPK signalingMacrophage primingLigand sensitivityHuman macrophagesInverse correlationInvasive pathogensSingle receptorGenes
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