2022
Frame-Guided Assembly of Amphiphiles
Dong Y, Yang Y, Lin C, Liu D. Frame-Guided Assembly of Amphiphiles. Accounts Of Chemical Research 2022, 55: 1938-1948. PMID: 35786832, DOI: 10.1021/acs.accounts.2c00234.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFrame-guided assemblyMolecular structureAssembly of amphiphilesArrangement of moleculesTraditional chemical industryMembrane protein incorporationProtein-lipid bilayerAmphiphilic assembliesAssembly morphologyAmphiphile assembliesFunctional nanomaterialsVersatile strategyAqueous environmentHydrophobic groupsHydrophobic moleculesFull surface areaHydrophobic interactionsAmphiphilesDrug deliveryMembrane proteinsFunctional complexAmphiphile concentrationAssembly strategyEPR effectNanomaterials
2017
Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water
Gunasekara RW, Zhao Y. Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water. Organic Letters 2017, 19: 4159-4162. PMID: 28753291, DOI: 10.1021/acs.orglett.7b01535.Peer-Reviewed Original Research
2003
Synthesis of a Diverse Library of Mechanism-Based Cysteine Protease Inhibitors
Wood WJ, Huang L, Ellman JA. Synthesis of a Diverse Library of Mechanism-Based Cysteine Protease Inhibitors. ACS Combinatorial Science 2003, 5: 869-880. PMID: 14606817, DOI: 10.1021/cc034008r.Peer-Reviewed Original ResearchConceptsKetone inhibitorsDiverse functionalitiesSolid-phase synthesisSingle-digit nanomolar inhibitorsPolar functionalitiesHydrophobic groupsDiverse libraryNanomolar inhibitorsSynthesisCysteine proteasesCysteine protease inhibitorsFmocChloromethyl ketonePotent inhibitorFunctionalityKetonesR2 siteAllocRich sourceR1Cathepsin B
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