2013
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation
Nickerson KM, Christensen SR, Cullen JL, Meng W, Prak E, Shlomchik MJ. TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation. The Journal Of Immunology 2013, 190: 1447-1456. PMID: 23296704, PMCID: PMC3563726, DOI: 10.4049/jimmunol.1202115.Peer-Reviewed Original ResearchConceptsAnti-DNA B cellsB cellsBone marrowAbsence of TLR9Autoimmune prone animalsAutoimmune-prone MRLSystemic lupus erythematosusAnergic B cellsB cell compartmentB cell toleranceAb-forming cellsL chain editingB cell life spanFunctional anergyLupus erythematosusTLR9 expressionAutoreactive cellsPeripheral activationExtrafollicular pathwayPeripheral repertoireSystemic autoimmunityMouse modelAnergic cellsTLR9Cell life span
2008
Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells*
Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG. Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells*. Journal Of Biological Chemistry 2008, 283: 27957-27972. PMID: 18662989, PMCID: PMC2562067, DOI: 10.1074/jbc.m803467200.Peer-Reviewed Original ResearchConceptsProliferative life spanNHP cellsMolecular mechanismsProgenitor cellsSuppression of p16Normal human prostate epithelial cellsGene expression profilesLife spanProstate epithelial progenitor cellsHuman prostate epithelial cellsRegulation of p16Activation of p53Prostate epithelial cellsEpithelial progenitor cellsCell proliferative capacityExpression profilesBasal-like cellsProgenitor markersMultilineage differentiationTelomerase expressionDistinct rolesCell life spanCell marker CD44P16 inhibitionEpithelial cells
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