1999
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
Mommaas A, Mulder A, Jordens R, Out C, Tan M, Cresswell P, Kluin P, Koning F. Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules. European Journal Of Immunology 1999, 29: 571-580. PMID: 10064073, DOI: 10.1002/(sici)1521-4141(199902)29:02<571::aid-immu571>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsHuman epidermal Langerhans cellsEpidermal Langerhans cellsLangerhans cellsT cellsAntigen-specific T cellsMannose receptorPeripheral blood mononuclear cellsHLA class II moleculesProtein antigensBlood-derived DCsBlood mononuclear cellsAntigen-presenting cellsNaive T cellsDendritic cell lineageClass II moleculesClass II compartmentsFunctional mannose receptorsLymph nodesAntigen uptakeMononuclear cellsMHC classEndocytic capacitySkin damageReceptor-mediated endocytosis pathwayAntigen
1991
Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes
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