2020
Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC
Hacker KP, Sacramento GA, Cruz JS, de Oliveira D, Nery N, Lindow JC, Carvalho M, Hagan J, Diggle PJ, Begon M, Reis MG, Wunder EA, Ko AI, Costa F. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 311-314. PMID: 31961288, PMCID: PMC6986844, DOI: 10.3201/eid2602.190102.Peer-Reviewed Original Research
2019
Elevated Activation of Neutrophil Toll-Like Receptors in Patients with Acute Severe Leptospirosis: An Observational Study.
Lindow JC, Tsay AJ, Montgomery RR, Reis EAG, Wunder EA, Araújo G, Nery NRR, Mohanty S, Shaw AC, Lee PJ, Reis MG, Ko AI. Elevated Activation of Neutrophil Toll-Like Receptors in Patients with Acute Severe Leptospirosis: An Observational Study. American Journal Of Tropical Medicine And Hygiene 2019, 101: 585-589. PMID: 31333152, PMCID: PMC6726964, DOI: 10.4269/ajtmh.19-0160.Peer-Reviewed Original ResearchConceptsSevere leptospirosisActivation markersDisease severityNeutrophil Toll-like receptorToll-like receptor 2Acute severe leptospirosisHospitalized leptospirosis patientsNeutrophil activation markersEarly immune responseToll-like receptorsSevere disease outcomesHigh initial bacterial loadFebrile infectionsOrgan dysfunctionLeptospirosis patientsPeripheral neutrophilsNeutrophil responseHealthy controlsImmune mechanismsDisease outcomeObservational studyImmune responseSevere diseaseReceptor 2Tissue damage
2016
Early Indicators of Fatal Leptospirosis during the 2010 Epidemic in Puerto Rico
Sharp TM, García B, Pérez-Padilla J, Galloway RL, Guerra M, Ryff KR, Haberling D, Ramakrishnan S, Shadomy S, Blau D, Tomashek KM, Bower WA. Early Indicators of Fatal Leptospirosis during the 2010 Epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2016, 10: e0004482. PMID: 26914210, PMCID: PMC4767218, DOI: 10.1371/journal.pntd.0004482.Peer-Reviewed Original ResearchConceptsFirst medical visitWhite blood cellsLeptospirosis patientsFatal outcomeMedical visitsFatal leptospirosisLaboratory valuesHospitalized leptospirosis patientsNon-fatal patientsRoutine laboratory valuesLeg painControl patientsMost patientsCase patientsHospital admissionMultivariable analysisIllness onsetPlatelet countDengue patientsFatal casesWBC countLeptospirosis epidemicPatientsMedical careOld male
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