2023
FXR agonists INT‐787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of NASH
Di Pasqua L, Cagna M, Palladini G, Croce A, Cadamuro M, Fabris L, Perlini S, Adorini L, Ferrigno A, Vairetti M. FXR agonists INT‐787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of NASH. Liver International 2023, 44: 214-227. PMID: 37904642, DOI: 10.1111/liv.15767.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisHigh-fat dietOb/ob mouse modelObeticholic acidAgonist obeticholic acidSerum alanine transaminaseAlanine transaminaseMMP-2MMP-9Mouse modelCollagen depositionHepatic ischaemia/reperfusion injuryFarnesoid X receptor agonist obeticholic acidControl dietFXR agonist obeticholic acidIschaemia/reperfusion injuryHepatic stellate cell activationMMP-9 activityStellate cell activationMMP-2 expressionΑ-SMA levelsOCA administrationHFD groupReperfusion injuryLiver steatosis
2018
Food withdrawal alters the gut microbiota and metabolome in mice
Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Qu C, Ge K, Huang F, Hernandez B, Yu H, Panee J, Chen T, Jia W, Jia W. Food withdrawal alters the gut microbiota and metabolome in mice. The FASEB Journal 2018, 32: 4878-4888. PMID: 29620942, PMCID: PMC9292403, DOI: 10.1096/fj.201700614r.Peer-Reviewed Original ResearchConceptsHigh-fat dietFood withdrawalGut microbiotaObese miceWithdrawal altersAbundance of microbesHost metabolic changesFree fatty acid metabolismBeneficial effectsNormal chow groupAbundance of metabolitesNormal lean miceFatty acid metabolismPathogenic ProteobacteriaMolecular mechanismsBranched-chain amino acidsHost serum metabolomeChain amino acidsCecal microbiomeAmino acidsHFD groupHFD miceDietary interventionLean miceNormal mice
2013
Lipid lowering and imaging protease activation in atherosclerosis
Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.Peer-Reviewed Original ResearchConceptsHigh-fat dietLipid-lowering interventionsHFD groupPlaque inflammationAtherosclerotic miceMicroSPECT/CT imagingTotal blood cholesterolModern therapeutic approachesSmooth muscle αMMP tracerFat dietBlood cholesterolPlaque biologyTherapeutic approachesTracer uptakeMatrix metalloproteinaseTherapeutic interventionsAtherosclerosisActin expressionCT imagingMuscle αWeeksFenofibrateMiceIntervention
2007
THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH
Mulligan‐Kehoe M, Drinane M, Mollmark J, Simons M. THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH. The FASEB Journal 2007, 21: a16-a17. DOI: 10.1096/fasebj.21.5.a16-d.Peer-Reviewed Original ResearchHigh-fat dietAnti-angiogenic activityVasa vasorumPlaque growthSaline treatmentPlaque areaPlaque progressionLumen areaRole of angiogenesisVasa vasorum densitySignificant anti-angiogenic activityAtherogenic micePlaque regressionHFD groupNeovascularized areaChow dietPAI-1 proteinFat dietAortic rootControl animalsVessel circumferenceVasorumVessel areaMiceReconstructed vessels
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